NO-independent stimulators of soluble guanylate cyclase.

Bioorganic & medicinal chemistry letters ·Vol. 11 ·No. 6 ·2001-03-26 ·Pages 781-4

Straub A, Stasch JP, Alonso-Alija C, Benet-Buchholz J, Ducke B, Feurer A, Fürstner C

Abstract

SARs around a novel type of guanylate cyclase stimulator which act by a mechanism different from classical NO-donors are described. Several pyrazolopyridinylpyrimidines are shown to relax aortic rings and revealed a long-lasting blood pressure lowering effect in rats after oral application.

MeSH Terms

Animals Aorta/drug effects,physiology Enzyme Activators/chemical synthesis,chemistry,pharmacology Guanylate Cyclase/metabolism Indazoles/chemical synthesis,chemistry,pharmacology Pyrazoles/chemistry,pharmacology Pyridines/chemistry,pharmacology Rabbits Structure-Activity Relationship Vasodilation/drug effects

Chemicals

3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine Enzyme Activators Indazoles Pyrazoles Pyridines 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole Guanylate Cyclase

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Straub A

Institute of Medicinal Chemistry, Pharma Research Centre, Bayer AG, Wuppertal, FRG. alexander.straub.as@bayer-ag.de

Stasch J P

Alonso-Alija C

Benet-Buchholz J

Ducke B

Feurer A

Fürstner C

Article Info

Journal

Bioorganic & medicinal chemistry letters

Abbr.

Bioorg Med Chem Lett

ISSN

0960-894X

DOI

10.1016/s0960-894x(01)00073-7

alexander.straub.as@bayer-ag.de

Published

2001-03-26

Pages

781-4

Language

English

Region

England

NLM ID

9107377

Subset

External Links

PubMed source DOI: 10.1016/s0960-894x(01)00073-7 View journal details

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NO-independent stimulators of soluble guanylate cyclase.

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