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PMID: 1127019 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Changes in distribution pattern of cytoplasmic filaments in human melanocytes during ultraviolet-mediated melanin pigmentation. The role of the 100-Angstrom filaments in the elongation of melanocytic dendrites and in the movement and transfer of melanosomes.

The Journal of cell biology ·Vol. 65 ·No. 2 ·1975-05-00 ·Pages 481-8

Jimbow K, Fitzpatrick TB

Abstract

Human melanocytes characteristically contain 100-A filaments. These 100-A filaments shift from the perinuclear area to the center of the dendritic processes and are in close association with melanosomes during the different stages of UV-mediated melanin pigmentation. We suggest that these 100-A filaments in human melanocytes participate in the elongation of the dendrites and in the transfer of melanosomes.

MeSH Terms

Buttocks Cytochalasin B/pharmacology Cytoplasm/physiology,ultrastructure Dendrites/ultrastructure Epithelial Cells Epithelium/ultrastructure Forearm Humans Melanins/biosynthesis Melanocytes/metabolism,ultrastructure Microscopy, Electron Microtubules/ultrastructure Organoids/ultrastructure Pigmentation/radiation effects Radiation Effects Skin/ultrastructure Time Factors Ultraviolet Rays Vincristine/pharmacology

Chemicals

Melanins Cytochalasin B Vincristine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Jimbow K

Fitzpatrick T B

References (13)

13 references, click to expand

Contact-inhibited revertant cell lines isolated from SV 40-transformed cells. IV. Microfilament distribution and cell shape in untransformed, transformed, and revertant Balb-c 3T3 cells.
J Cell Biol. 1973 Feb;56(2):412-28 PMID: 4345552
Observations on the association of helical polyribosomes and filaments with vincristine-induced crystals in Earle's L-cell fibroblasts.
J Cell Biol. 1969 Dec;43(3):553-63 PMID: 5351406
Ultrastructure and function of growth cones and axons of cultured nerve cells.
J Cell Biol. 1971 Jun;49(3):614-35 PMID: 4326456
Cytochalasin B: effects on microfilaments and movement of melanin granules within melanocytes.
Science. 1972 Feb 11;175(4022):642-4 PMID: 4536685
The effects of parathyroid hormone, colchicine, and calcitonin on the ultrastructure and the activity of osteoclasts in organ culture.
J Cell Biol. 1974 Feb;60(2):346-55 PMID: 4855901
Microtubules, microfilaments, and pigment movement in the chromatophores of Palaemonetes vulgaris (Crustacea).
J Exp Zool. 1973 Dec;186(3):279-304 PMID: 4765352
Fine structural changes in neurons and nerve fibers associated with colchicine inhibition of nerve fiber formation in vitro.
J Cell Biol. 1973 Aug;58(2):463-70 PMID: 4738107
Effects of cytochalasin B on mammalian melanocytes and keratinocytes.
J Invest Dermatol. 1972 Aug;59(2):163-9 PMID: 5050347
The structure of the major cell processes of isolated BHK21 fibroblasts.
Exp Cell Res. 1969 Oct;57(2):263-76 PMID: 4899847
Isolation of filaments from brain.
Science. 1971 Dec 17;174(4015):1242-5 PMID: 5133446
The melanocyte model. Colchicine-like effects of other antimitotic agents.
J Cell Biol. 1971 Jun;49(3):848-55 PMID: 5559844
Fibrillar proteins from squid axons. I. Neurofilament protein.
J Mol Biol. 1970 Sep 28;52(3):415-28 PMID: 5492289
Formation of arrowhead complexes with heavy meromyosin in a variety of cell types.
J Cell Biol. 1969 Nov;43(2):312-28 PMID: 5344150

Article Info

Journal

The Journal of cell biology

Abbr.

J Cell Biol

ISSN

0021-9525

DOI

10.1083/jcb.65.2.481

Published

1975-05-00

Pages

481-8

Language

English

Region

United States

NLM ID

0375356

PMCID

PMC2109431

Subset

External Links

PubMed source DOI: 10.1083/jcb.65.2.481 PMC Full Text View journal details

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Changes in distribution pattern of cytoplasmic filaments in human melanocytes during ultraviolet-mediated melanin pigmentation. The role of the 100-Angstrom filaments in the elongation of melanocytic dendrites and in the movement and transfer of melanosomes.

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