Molecular dissection of autophagy: two ubiquitin-like systems.

Nature reviews. Molecular cell biology ·Vol. 2 ·No. 3 ·2001-03-00 ·Pages 211-6

Ohsumi Y

Abstract

Recent analyses of the genes required for autophagy--intracellular bulk protein degradation--in yeast have revealed two ubiquitin-like systems, both of which are involved in the membrane dynamics of the process. Molecular dissection of these systems is now revealing some surprises.

MeSH Terms

Autophagy/physiology Autophagy-Related Protein 7 Autophagy-Related Protein 8 Family Lysosomes/metabolism Microscopy, Electron Microtubule-Associated Proteins/metabolism Models, Biological Proteins/metabolism Saccharomyces cerevisiae/physiology,ultrastructure Saccharomyces cerevisiae Proteins Ubiquitins/metabolism Vacuoles/metabolism

Chemicals

ATG7 protein, S cerevisiae ATG8 protein, S cerevisiae Autophagy-Related Protein 8 Family Microtubule-Associated Proteins Proteins Saccharomyces cerevisiae Proteins Ubiquitins Autophagy-Related Protein 7

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Ohsumi Y

Department of Cell Biology, National Institute for Basic Biology, Myodaiji, Okazaki, 444-8585, Japan. yohsumi@nibb.ac.jp

Article Info

Journal

Nature reviews. Molecular cell biology

Abbr.

Nat Rev Mol Cell Biol

ISSN

1471-0072

DOI

10.1038/35056522

yohsumi@nibb.ac.jp

Published

2001-03-00

Pages

211-6

Language

English

Region

England

NLM ID

100962782

Subset

External Links

PubMed source DOI: 10.1038/35056522 View journal details

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Molecular dissection of autophagy: two ubiquitin-like systems.

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