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PMID: 11252896 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Are desmosomes more than tethers for intermediate filaments?

Nature reviews. Molecular cell biology ·Vol. 1 ·No. 3 ·2000-12-00 ·Pages 208-16

Green KJ, Gaudry CA

Abstract

Desmosomes are intercellular adhesive junctions that anchor intermediate filaments at membrane-associated plaques in adjoining cells, thereby forming a three-dimensional supracellular scaffolding that provides tissues with mechanical strength. But desmosomes have also recently been recognized as sensors that respond to environmental and cellular cues by modulating their assembly state and, possibly, their signalling functions.

MeSH Terms

Animals Cadherins/genetics Cytoskeletal Proteins/genetics Desmoglein 1 Desmoglein 3 Desmoplakins Desmosomes/physiology Epithelium/metabolism Humans Intermediate Filaments/physiology Mice Models, Biological Plakophilins Proteins/genetics Signal Transduction

Chemicals

Cadherins Cytoskeletal Proteins DSG3 protein, human Desmoglein 1 Desmoglein 3 Desmoplakins Plakophilins Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Green K J

Departments of Pathology and Dermatology and the Robert H. Lurie Cancer Center, Northwestern University Medical School, Chicago, Illinois 60611, USA. kgreen@nwu.edu

Gaudry C A

Article Info

Journal

Nature reviews. Molecular cell biology

Abbr.

Nat Rev Mol Cell Biol

ISSN

1471-0072

DOI

10.1038/35043032

kgreen@nwu.edu

Published

2000-12-00

Pages

208-16

Language

English

Region

England

NLM ID

100962782

Subset

External Links

PubMed source DOI: 10.1038/35043032 View journal details

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Are desmosomes more than tethers for intermediate filaments?

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