Transforming growth factor-beta and breast cancer: Lessons learned from genetically altered mouse models.

Breast cancer research : BCR ·Vol. 2 ·No. 2 ·2000-00-00 ·Pages 100-6

Wakefield LM, Yang YA, Dukhanina O

Abstract

Transforming growth factor (TGF)-betas are plausible candidate tumor suppressors in the breast. They also have oncogenic activities under certain circumstances, however. Genetically altered mouse models provide powerful tools to analyze the complexities of TGF-beta action in the context of the whole animal. Overexpression of TGF-beta can suppress tumorigenesis in the mammary gland, raising the possibility that use of pharmacologic agents to enhance TGF-beta function locally might be an effective method for the chemoprevention of breast cancer. Conversely, loss of TGF-beta response increases spontaneous and induced tumorigenesis in the mammary gland. This confirms that endogenous TGF-betas have tumor suppressor activity in the mammary gland, and suggests that the loss of TGF-beta receptors seen in some human breast hyperplasias may play a causal role in tumor development.

MeSH Terms

Animals Female Genes, Tumor Suppressor/physiology Genetic Engineering Humans Mammary Neoplasms, Experimental/metabolism Mice Mice, Transgenic/metabolism Receptors, Transforming Growth Factor beta/metabolism Transforming Growth Factor beta/physiology

Chemicals

Receptors, Transforming Growth Factor beta Transforming Growth Factor beta

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Wakefield L M

Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, 41 Library DR MSC 5055, Bethesda, MD 20892, USA. wakefiel@dce41.nci.nih.gov

Yang Y A

Dukhanina O

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Article Info

Journal

Breast cancer research : BCR

Abbr.

Breast Cancer Res

ISSN

1465-5411

DOI

10.1186/bcr41

wakefiel@dce41.nci.nih.gov

Published

2000-00-00

Epub

2000-00-21

Pages

100-6

Language

English

Region

England

NLM ID

100927353

PMCID

PMC139431

Subset

External Links

PubMed source DOI: 10.1186/bcr41 PMC Full Text View journal details

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Transforming growth factor-beta and breast cancer: Lessons learned from genetically altered mouse models.

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