Chromosome movement: dynein-out at the kinetochore.

Current biology : CB ·Vol. 11 ·No. 4 ·2001-02-20 ·Pages R128-31

Banks JD, Heald R

Abstract

Cell biologists have long speculated that a minus end-directed motor localized at kinetochores contributes to the poleward movement of chromosomes during mitosis. Two recent studies provide direct evidence that cytoplasmic dynein can perform this function.

MeSH Terms

Animals CDC2 Protein Kinase/metabolism Cell Cycle Proteins Chromosomal Proteins, Non-Histone/metabolism Chromosomes/physiology Cyclin B/metabolism Drosophila Proteins Dynactin Complex Dyneins/metabolism,physiology Insect Proteins/metabolism Kinesins/metabolism Kinetochores/metabolism,physiology Meiosis/physiology Microtubule-Associated Proteins/metabolism Mitosis/physiology Spindle Apparatus/metabolism,physiology Xenopus Proteins

Chemicals

Cell Cycle Proteins Chromosomal Proteins, Non-Histone CycB protein, Drosophila Cyclin B Drosophila Proteins Dynactin Complex Insect Proteins KIF11 protein, Xenopus KIF2C protein, human Microtubule-Associated Proteins Xenopus Proteins centromere protein E Zw10 protein, Drosophila CDC2 Protein Kinase Dyneins Kinesins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Banks J D

Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3200, USA. jenbanks@uclink4.berkeley.edu

Heald R

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(01)00059-8

jenbanks@uclink4.berkeley.edu

Published

2001-02-20

Pages

R128-31

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(01)00059-8 View journal details

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Chromosome movement: dynein-out at the kinetochore.

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