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PMID: 11248007 Published · ppublish English Comment Journal Article Review

Chemoprevention: increased potential to bear fruit.

Wolf CR

Abstract

暂无摘要

MeSH Terms
Animals Anticarcinogenic Agents/metabolism,pharmacology Antioxidants/metabolism Carrier Proteins/metabolism Cytochrome P-450 Enzyme System/metabolism DNA-Binding Proteins/metabolism,physiology Glutathione Transferase/metabolism Humans NF-E2-Related Factor 2 Response Elements Sulfhydryl Compounds/metabolism,pharmacology Trans-Activators/metabolism,physiology
Chemicals
Anticarcinogenic Agents Antioxidants Carrier Proteins DNA-Binding Proteins NF-E2-Related Factor 2 NFE2L2 protein, human Sulfhydryl Compounds Trans-Activators Cytochrome P-450 Enzyme System Glutathione Transferase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Wolf C R
Imperial Cancer Research Fund Molecular Pharmacology Unit, Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom. rooney@icrf.icnet.uk
References (26)
26 references, click to expand
  1. Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China.
    J Natl Cancer Inst. 1999 Feb 17;91(4):347-54 PMID: 10050868
  2. The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene.
    Cancer Res. 1956 Jun;16(5):450-9 PMID: 13330038
  3. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.
    Biochem Biophys Res Commun. 1997 Jul 18;236(2):313-22 PMID: 9240432
  4. Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress.
    Biochem Soc Symp. 1999;64:141-68 PMID: 10207627
  5. Vegetables, fruit, and cancer. I. Epidemiology.
    Cancer Causes Control. 1991 Sep;2(5):325-57 PMID: 1834240
  6. Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene.
    Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14960-5 PMID: 8962164
  7. Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis.
    Proc Natl Acad Sci U S A. 1988 Nov;85(21):8261-5 PMID: 3141925
  8. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.
    Genes Dev. 1999 Jan 1;13(1):76-86 PMID: 9887101
  9. Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen.
    Free Radic Biol Med. 2000 Aug;29(3-4):231-40 PMID: 11035251
  10. Nrf2 is essential for protection against acute pulmonary injury in mice.
    Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12731-6 PMID: 10535991
  11. Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants.
    Cancer Res. 1978 Dec;38(12):4486-95 PMID: 363262
  12. Stimulatory effect of brussels sprouts and cabbage on human drug metabolism.
    Clin Pharmacol Ther. 1979 Jan;25(1):88-95 PMID: 758247
  13. Ranking possible carcinogenic hazards.
    Science. 1987 Apr 17;236(4799):271-80 PMID: 3563506
  14. Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups.
    Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3404-9 PMID: 11248091
  15. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.
    Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5 PMID: 11248092
  16. Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity.
    Proc Natl Acad Sci U S A. 1980 Sep;77(9):5216-20 PMID: 6933553
  17. Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds.
    Proc Natl Acad Sci U S A. 1990 May;87(10):3826-30 PMID: 2160079
  18. Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals.
    J Biol Chem. 1999 Sep 24;274(39):27545-52 PMID: 10488090
  19. The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin.
    Biochem Soc Trans. 2000 Feb;28(2):33-41 PMID: 10816095
  20. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases.
    Science. 1983 Sep 23;221(4617):1256-64 PMID: 6351251
  21. Metabolic factors in cancer susceptibility.
    Cancer Surv. 1990;9(3):437-74 PMID: 2101721
  22. Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases.
    Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5275-80 PMID: 9560266
  23. A conserved region adjacent to the basic domain is required for recognition of an extended DNA binding site by Maf/Nrl family proteins.
    Oncogene. 1994 Nov;9(11):3149-58 PMID: 7936637
  24. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.
    Crit Rev Biochem Mol Biol. 1995;30(6):445-600 PMID: 8770536
  25. Inhibitors of chemical carcinogenesis.
    Adv Cancer Res. 1978;26:197-226 PMID: 204165
  26. Chemoprevention of cancer.
    Cancer Res. 1985 Jan;45(1):1-8 PMID: 3880665
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
2001-03-13
Pages
2941-3
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC33333
Subset
IM
Corrections
CommentOn
CommentOn
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