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题目:: Lymphoid environment limits superantigen and antigen-induced T cell proliferation at high precursor frequency.
作者:: Attinger(A),MacDonald(H R),Acha-Orbea(H)
状态:: 发布时间2001-03-12 , 更新时间 2006-11-15
期刊:: Eur J Immunol
摘要:: After superantigen challenge a significant proportion of superantigen-reactive T cells remain undivided. We provide evidence that the lymphoid environment limits T cell proliferation in the secondary lymphoid organs when the frequency of superantigen reactive T cells is unusually high. We monitored T cell proliferation and the percentage of undivided cells when the frequency of superantigen-reactive T cells was low (1%), intermediate (15%) or high (30-100%) by transferring fluorescently labeled cells into different recipients. When the frequency was low, practically all the reactive T cells entered cell cycle and proliferated maximally. At intermediate frequencies a large proportion of reactive T cells did not enter cell cycle and the whole population divided less. A further increase in reactive T cells did not alter the percentage of undivided cells but induced a further decrease in the number of cell divisions. Interestingly, the observations made with superantigens were confirmed with peptide antigen and TCR-transgenic mice. Moreover, in vivo and in vitro data suggest that dendritic cells are the most likely candidates in limiting T cell proliferation in the lymphoid environment. In conclusion, we show that the availability of APC in the lymphoid environment can quantitatively limit T cell priming.
语言:: eng
DOI:: 10.1002/1521-4141(200103)31:3<884::AID-IMMU884>3.0.CO;2-M

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