MeSH Terms
Aminoglycosides
Animals
Anti-Bacterial Agents/adverse effects,pharmacology
Cardiomyopathy, Dilated/genetics
Cataract/genetics
Chimera
Chloramphenicol Resistance/genetics
DNA, Mitochondrial/genetics
DNA, Ribosomal/genetics
Disease Models, Animal
Embryo Transfer
Female
Genes, Reporter
Humans
Mice
Mice, Inbred NZB
Mice, Transgenic/genetics
Microinjections
Mitochondrial Myopathies/genetics
Phenotype
Point Mutation
Protein Biosynthesis/drug effects
RNA, Ribosomal/chemistry,genetics
RNA, Ribosomal, 16S/chemistry,genetics
Stem Cells/metabolism
Transfection
Chemicals
Aminoglycosides
Anti-Bacterial Agents
DNA, Mitochondrial
DNA, Ribosomal
RNA, Ribosomal
RNA, Ribosomal, 16S
RNA, ribosomal, 12S
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hirano M
Department of Neurology, Columbia-Presbyterian Medical Center, 630 West 168th Street, P&S 4-443, New York, NY 10032, USA. mh29@columbia.edu
References (19)
19 references, click to expand
-
Mutations in mtDNA: are we scraping the bottom of the barrel?
Brain Pathol. 2000 Jul;10(3):431-41
PMID: 10885662
-
Transfer of chloramphenicol-resistant mitochondrial DNA into the chimeric mouse.
Transgenic Res. 1999 Apr;8(2):137-45
PMID: 10481313
-
A debut for mito-mouse.
Nat Genet. 2000 Oct;26(2):132-4
PMID: 11017060
-
Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes.
Nat Genet. 2000 Oct;26(2):176-81
PMID: 11017072
-
Maternal germ-line transmission of mutant mtDNAs from embryonic stem cell-derived chimeric mice.
Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14461-6
PMID: 11106380
-
Teratocarcinoma cells as vehicles for introducing specific mutant mitochondrial genes into mice.
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5113-7
PMID: 283419
-
Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies.
Nature. 1988 Feb 25;331(6158):717-9
PMID: 2830540
-
Deletions of mitochondrial DNA in Kearns-Sayre syndrome.
Neurology. 1988 Sep;38(9):1339-46
PMID: 3412580
-
Mitochondrial DNA deletion in Pearson's marrow/pancreas syndrome.
Lancet. 1989 Apr 22;1(8643):902-3
PMID: 2564980
-
Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation.
Science. 1989 Oct 27;246(4929):500-3
PMID: 2814477
-
Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness.
Nat Genet. 1993 Jul;4(3):289-94
PMID: 7689389
-
Mutant mtDNA at 1555 A to G in 12S rRNA gene and hypersusceptibility of mitochondrial translation to streptomycin can be co-transferred to rho 0 HeLa cells.
Biochem Biophys Res Commun. 1996 Jun 25;223(3):496-501
PMID: 8687424
-
Biochemical evidence for nuclear gene involvement in phenotype of non-syndromic deafness associated with mitochondrial 12S rRNA mutation.
Hum Mol Genet. 1996 Jul;5(7):963-71
PMID: 8817331
-
Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA.
Nat Genet. 1996 Oct;14(2):146-51
PMID: 8841183
-
Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice.
Nat Genet. 1997 May;16(1):93-5
PMID: 9140402
-
Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice.
Nat Genet. 1998 Mar;18(3):231-6
PMID: 9500544
-
Maternally inherited cardiomyopathy: an atypical presentation of the mtDNA 12S rRNA gene A1555G mutation.
Am J Hum Genet. 1999 Jan;64(1):295-300
PMID: 9915970
-
Mitochondrial diseases in man and mouse.
Science. 1999 Mar 5;283(5407):1482-8
PMID: 10066162
-
Transmitochondrial mice carrying resistance to chloramphenicol on mitochondrial DNA: developing the first mouse model of mitochondrial DNA disease.
Nat Med. 1999 Aug;5(8):957-60
PMID: 10426324