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PMID: 11208140 Published · ppublish English Journal Article Review

Folding of viral envelope glycoproteins in the endoplasmic reticulum.

Traffic (Copenhagen, Denmark) ·Vol. 1 ·No. 7 ·2000-07-00 ·Pages 533-9

Braakman I, van Anken E

Abstract

Viral glycoproteins fold and oligomerize in the endoplasmic reticulum of the host cell. They employ the cellular machinery and receive assistance from cellular folding factors. During the folding process, they are retained in the compartment and their structural quality is checked by the quality control system of the endoplasmic reticulum. A special characteristic that distinguishes viral fusion proteins from most cellular proteins is the extensive conformational change they undergo during fusion of the viral and cellular membrane. Many viral proteins fold in conjunction with and dependent on a viral partner protein, sometimes even synthesized from the same mRNA. Relevant for folding is that viral glycoproteins from the same or related virus families may consist of overlapping sets of domain modules. The consequences of these features for viral protein folding are at the heart of this review.

MeSH Terms
Animals Calcium-Binding Proteins/physiology Calnexin Calreticulin Cystine/physiology Endoplasmic Reticulum/physiology Evolution, Molecular Glycosylation Hemagglutinin Glycoproteins, Influenza Virus/chemistry,physiology Humans Molecular Chaperones/physiology Protein Conformation Protein Folding Protein Processing, Post-Translational Ribonucleoproteins/physiology Structure-Activity Relationship Viral Envelope Proteins/chemistry,genetics,physiology Viral Fusion Proteins/chemistry,genetics,physiology
Chemicals
Calcium-Binding Proteins Calreticulin Hemagglutinin Glycoproteins, Influenza Virus Molecular Chaperones Ribonucleoproteins Viral Envelope Proteins Viral Fusion Proteins Calnexin Cystine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Braakman I
Department of Bio-Organic Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, The Netherlands. braakman@chem.uu.nl
van Anken E
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Article Info
Journal
Traffic (Copenhagen, Denmark)
Abbr.
Traffic
ISSN
1398-9219
DOI
10.1034/j.1600-0854.2000.010702.x
Email
braakman@chem.uu.nl
Published
2000-07-00
Pages
533-9
Language
English
Region
England
NLM ID
100939340
PMCID
PMC7190097
Subset
IM
External Links
PubMed source DOI: 10.1034/j.1600-0854.2000.010702.x PMC Full Text View journal details
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