[The expression of nm23-H1 and p53 protein in nasopharyngeal carcinoma].

To evaluate the role of nm23-H1 and p53 protein expression in Nasopharyngeal Carcinoma (NPC), the S-P immunohistochemical method was used to detect the expression of nm23-H1 and p53 protein in 125 cases of NPC. The positive expression for nm23-H1 and p53 were 50.4%(63/125), 90.4%(113/125), respectively nm23-H1 expression in the NPC with cervical lymph node metastasis and without cervical lymph node metastasis were 27.9%(17/61) and 71.9%(46/64), respectively (P < 0.001). 1. Mutations of p53 may play a role in carcinogenesis of NPC. 2. The difference between the NPC with cervical lymph node metastasis and without cervical lymph node metastasis for nm23-H1 expression was significant. The nm23-H1 gene may play a role in antimetastasis of NPC.