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PMID: 11187835 Published · ppublish English Comment Journal Article

Microbiology. Action at a distance--bacterial flagellar assembly.

Science (New York, N.Y.) ·Vol. 290 ·No. 5499 ·2000-12-15 ·Pages 2086-7

Macnab RM

Abstract

The rotating motion of a helical flagellum enables a bacterium to swim toward positive stimuli and away from danger. But how is the flagellum, composed of many different proteins, assembled? In a Perspective, Macnab explains how subunits of the protein flagellin flow down a channel inside the flagellum and are then added to its tip through the action of a rotating pentameric cap complex (Yonekura et al.).

MeSH Terms
Bacteria/ultrastructure Bacterial Proteins/chemistry,metabolism Cryoelectron Microscopy Diffusion Flagella/metabolism,ultrastructure Flagellin/chemistry,metabolism Protein Conformation Protein Folding Protein Structure, Quaternary Protein Structure, Secondary
Chemicals
Bacterial Proteins Flagellin FlaD protein, Bacteria
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Macnab R M
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. robert.macnab@yale.edu
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
Published
2000-12-15
Pages
2086-7
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Corrections
CommentOn
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