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PMID: 11179804 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Redox-operated genetic switches: the SoxR and OxyR transcription factors.

Trends in biotechnology ·Vol. 19 ·No. 3 ·2001-03-00 ·Pages 109-14

Pomposiello PJ, Demple B

Abstract

Two redox-responsive transcription regulators have been well defined in Escherichia coli and serve as paradigms of redox-operated genetic switches. SoxR contains iron-sulfur centers that activate the protein when they are one-electron oxidized, or nitrosylated by nitric oxide. OxyR contains a pair of redox-active cysteine residues that activate the protein when they are oxidized to form a disulfide bond.

MeSH Terms

Bacterial Proteins/chemistry,genetics,metabolism Biotechnology DNA-Binding Proteins Disulfides/chemistry Escherichia coli/genetics,metabolism Escherichia coli Proteins Free Radicals/metabolism Hydrogen Peroxide/metabolism Nitric Oxide/metabolism Oxidation-Reduction Repressor Proteins/chemistry,genetics,metabolism Superoxides/metabolism Transcription Factors/chemistry,genetics,metabolism Transcriptional Activation

Chemicals

Bacterial Proteins DNA-Binding Proteins Disulfides Escherichia coli Proteins Free Radicals Repressor Proteins Transcription Factors oxyR protein, E coli Superoxides SoxR protein, Bacteria Nitric Oxide Hydrogen Peroxide

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Pomposiello P J

Dept of Cancer Cell Biology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.

Demple B

Article Info

Journal

Trends in biotechnology

Abbr.

Trends Biotechnol

ISSN

0167-7799

DOI

10.1016/s0167-7799(00)01542-0

Published

2001-03-00

Pages

109-14

Language

English

Region

England

NLM ID

8310903

Subset

External Links

PubMed source DOI: 10.1016/s0167-7799(00)01542-0 View journal details

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Redox-operated genetic switches: the SoxR and OxyR transcription factors.

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