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PMID: 11175356 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Review

Genetic analysis of ETS genes in C. elegans.

Oncogene ·Vol. 19 ·No. 55 ·2000-12-18 ·Pages 6400-8

Hart AH, Reventar R, Bernstein A

Abstract

The recent completion of the Caenorhabditis elegans genome has revealed that this nematode worm has 10 members of the ETS gene family. Isolation and analysis of C. elegans mutants and subsequent screens to identify interacting genes can proceed very quickly in this model organism. Molecular genetic analysis of the receptor tyrosine kinase-Ras-MAP kinase signaling pathway in C. elegans identified the ETS family transcription factor Lin-1 as a nuclear effector of this evolutionarily conserved signal transduction pathway. Here we review classical genetic approaches used to discover the role of Lin-1 in the Ras-MAP kinase signaling pathway and describe new technologies that can be applied to the analyses of signaling pathways and transcription factor regulatory networks in C. elegans.

MeSH Terms

Amino Acid Sequence Animals Caenorhabditis elegans/genetics Caenorhabditis elegans Proteins Cell Lineage DNA-Binding Proteins/genetics,physiology Dimerization Disorders of Sex Development/genetics Evolution, Molecular Female Forecasting Gene Expression Profiling Gene Expression Regulation Gene Targeting Genes, Helminth Genetic Techniques Helminth Proteins/genetics,physiology Humans Larva MAP Kinase Signaling System/genetics Male Mice Models, Animal Molecular Sequence Data Morphogenesis Multigene Family Mutagenesis, Site-Directed Oncogene Proteins/genetics Phylogeny Proteome Proto-Oncogene Protein c-fli-1 Proto-Oncogene Proteins Receptor Protein-Tyrosine Kinases/physiology Sequence Alignment Sequence Homology, Amino Acid Trans-Activators/genetics Transcription Factors/genetics,physiology Transcriptional Regulator ERG Vulva/cytology,growth & development ras Proteins/physiology

Chemicals

Caenorhabditis elegans Proteins DNA-Binding Proteins ERG protein, human Fli1 protein, mouse Helminth Proteins Lin-1 protein, C elegans Oncogene Proteins Proteome Proto-Oncogene Protein c-fli-1 Proto-Oncogene Proteins Trans-Activators Transcription Factors Transcriptional Regulator ERG lin-31 protein, C elegans Receptor Protein-Tyrosine Kinases ras Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Hart A H

Program of Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5.

Reventar R

Bernstein A

Article Info

Journal

Oncogene

Abbr.

Oncogene

ISSN

0950-9232

DOI

10.1038/sj.onc.1204040

Published

2000-12-18

Pages

6400-8

Language

English

Region

England

NLM ID

8711562

Subset

External Links

PubMed source DOI: 10.1038/sj.onc.1204040 View journal details

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