Polyphyletic evolution of type II restriction enzymes revisited: two independent sources of second-hand folds revealed.

Trends in biochemical sciences ·第 26 卷 ·第 1 期 ·2001-05-21

Bujnicki J M, Radlinska M, Rychlewski L

摘要

Using algorithms for protein sequence analysis we predict that some of the canonical type II and type IIS restriction enzymes have an active site with a substantially different architecture and fold from the "typical" PD-(D/E)xK superfamily. These results suggest that they are related to nucleases from the HNH and GIY-YIG superfamilies.

文献信息

期刊

Trends in biochemical sciences

期刊简称

Trends Biochem Sci

ISSN

0968-0004

发表日期

2001-05-21

收录日期

2001-02-22

更新日期

2013-11-21

语言

英语

国家/地区

England

NLM ID

7610674

外部链接

PubMed 原文查看期刊详情

分析服务

Polyphyletic evolution of type II restriction enzymes revisited: two independent sources of second-hand folds revealed.

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