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PMID: 11163156 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Mitotic checkpoints: from yeast to cancer.

Current opinion in genetics & development ·Vol. 11 ·No. 1 ·2001-02-00 ·Pages 83-90

Wassmann K, Benezra R

Abstract

Separation of chromosomes during mitosis is monitored by a checkpoint that leads to cell-cycle arrest if the chromosomes are not properly attached to the mitotic spindle. Molecular mechanisms controlling this checkpoint have been identified. In addition, loss of this checkpoint has been shown to result in chromosome missegregation in higher eukaryotes and may contribute to the genomic instability observed in human cancers.

MeSH Terms

Adenomatous Polyposis Coli Protein Anaphase/genetics Animals Cytoskeletal Proteins/metabolism Genes, cdc Humans Kinetochores/metabolism Metaphase/genetics Mitosis/genetics Neoplasms/pathology Spindle Apparatus/metabolism Yeasts/cytology

Chemicals

Adenomatous Polyposis Coli Protein Cytoskeletal Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wassmann K

Cell Biology Program, Memorial Sloan-Kettering Cancer Center and the Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, Box 241, 1275 York Avenue, New York, New York 10021, USA.

Benezra R

Article Info

Journal

Current opinion in genetics & development

Abbr.

Curr Opin Genet Dev

ISSN

0959-437X

DOI

10.1016/s0959-437x(00)00161-1

Published

2001-02-00

Pages

83-90

Language

English

Region

England

NLM ID

9111375

Subset

Grants

NIGMS NIH HHS · GM 54601 · United States

External Links

PubMed source DOI: 10.1016/s0959-437x(00)00161-1 View journal details

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Mitotic checkpoints: from yeast to cancer.

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