Abstract
The von Hippel-Lindau tumor suppressor protein (pVHL) has been shown to bind directly to the alpha subunits of the heterodimeric transcription factor HIF (hypoxia inducible factor). pVHL directs the polyubiquitination and, hence, destruction of HIF in the presence of oxygen. Loss of pVHL function leads to deregulation of HIF target genes, which play critical roles in angiogenesis.
MeSH Terms
Animals
Aryl Hydrocarbon Receptor Nuclear Translocator
Cell Cycle
Cell Cycle Proteins/metabolism
Chaperonin Containing TCP-1
Chaperonins/metabolism
Cullin Proteins
DNA-Binding Proteins/genetics,metabolism
Elongin
Extracellular Matrix/metabolism
Genes, Tumor Suppressor
Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor 1, alpha Subunit
Isoenzymes/metabolism
Ligases
Nuclear Proteins/genetics,metabolism
Protein Kinase C/metabolism
Proteins/genetics,metabolism
Receptors, Aryl Hydrocarbon
Transcription Factors/genetics,metabolism
Transcription, Genetic
Tumor Suppressor Proteins
Ubiquitin-Protein Ligases
Ubiquitins/metabolism
Von Hippel-Lindau Tumor Suppressor Protein
von Hippel-Lindau Disease/genetics
Chemicals
CUL2 protein, human
Cell Cycle Proteins
Cullin Proteins
DNA-Binding Proteins
Elongin
Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor 1, alpha Subunit
Isoenzymes
Nuclear Proteins
Proteins
Receptors, Aryl Hydrocarbon
Transcription Factors
Tumor Suppressor Proteins
Ubiquitins
Aryl Hydrocarbon Receptor Nuclear Translocator
Ubiquitin-Protein Ligases
Von Hippel-Lindau Tumor Suppressor Protein
Protein Kinase C
Chaperonin Containing TCP-1
Chaperonins
Ligases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ivan M
Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Womens Hospital, 44 Binney Street, Boston, Massachusetts 02115, USA.
Kaelin W G