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PMID: 11163147 Published · ppublish English Journal Article Review

The von Hippel-Lindau tumor suppressor protein.

Current opinion in genetics & development ·Vol. 11 ·No. 1 ·2001-02-00 ·Pages 27-34

Ivan M, Kaelin WG

Abstract

The von Hippel-Lindau tumor suppressor protein (pVHL) has been shown to bind directly to the alpha subunits of the heterodimeric transcription factor HIF (hypoxia inducible factor). pVHL directs the polyubiquitination and, hence, destruction of HIF in the presence of oxygen. Loss of pVHL function leads to deregulation of HIF target genes, which play critical roles in angiogenesis.

MeSH Terms
Animals Aryl Hydrocarbon Receptor Nuclear Translocator Cell Cycle Cell Cycle Proteins/metabolism Chaperonin Containing TCP-1 Chaperonins/metabolism Cullin Proteins DNA-Binding Proteins/genetics,metabolism Elongin Extracellular Matrix/metabolism Genes, Tumor Suppressor Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Isoenzymes/metabolism Ligases Nuclear Proteins/genetics,metabolism Protein Kinase C/metabolism Proteins/genetics,metabolism Receptors, Aryl Hydrocarbon Transcription Factors/genetics,metabolism Transcription, Genetic Tumor Suppressor Proteins Ubiquitin-Protein Ligases Ubiquitins/metabolism Von Hippel-Lindau Tumor Suppressor Protein von Hippel-Lindau Disease/genetics
Chemicals
CUL2 protein, human Cell Cycle Proteins Cullin Proteins DNA-Binding Proteins Elongin Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Isoenzymes Nuclear Proteins Proteins Receptors, Aryl Hydrocarbon Transcription Factors Tumor Suppressor Proteins Ubiquitins Aryl Hydrocarbon Receptor Nuclear Translocator Ubiquitin-Protein Ligases Von Hippel-Lindau Tumor Suppressor Protein Protein Kinase C Chaperonin Containing TCP-1 Chaperonins Ligases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ivan M
Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Womens Hospital, 44 Binney Street, Boston, Massachusetts 02115, USA.
Kaelin W G
Article Info
Journal
Current opinion in genetics & development
Abbr.
Curr Opin Genet Dev
ISSN
0959-437X
Published
2001-02-00
Pages
27-34
Language
English
Region
England
NLM ID
9111375
Subset
IM
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