Conformational changes during kinesin motility.

Current opinion in cell biology ·Vol. 13 ·No. 1 ·2001-02-00 ·Pages 19-28

Schief WR, Howard J

Abstract

Nucleotide-dependent movements of the head and neck of kinesin have been visualized by cryoelectron microscopy and have been inferred from single-molecule studies. Key predictions of the hand-over-hand model for dimeric kinesin have been confirmed, and a novel processivity mechanism for the one-headed, kinesin-related motor KIF1A has been discovered.

MeSH Terms

Animals Kinesins/chemistry,metabolism Models, Molecular Molecular Motor Proteins/chemistry,metabolism Protein Conformation

Chemicals

Molecular Motor Proteins Kinesins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Schief W R

Department of Physiology & Biophysics, University of Washington, Box 357290, Seattle, Washington 98195-2790, USA. schief@u.washington.edu

Howard J

Article Info

Journal

Current opinion in cell biology

Abbr.

Curr Opin Cell Biol

ISSN

0955-0674

DOI

10.1016/s0955-0674(00)00169-1

schief@u.washington.edu

Published

2001-02-00

Pages

19-28

Language

English

Region

England

NLM ID

8913428

Subset

External Links

PubMed source DOI: 10.1016/s0955-0674(00)00169-1 View journal details

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Conformational changes during kinesin motility.

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