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PMID: 11158601 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

An orphaned mammalian beta-globin gene of ancient evolutionary origin.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 98 ·No. 3 ·2001-01-30 ·Pages 1101-6

Wheeler D, Hope R, Cooper SB, Dolman G, Webb GC, Bottema CD, Gooley AA, Goodman M, Holland RA

Abstract

Mammals possess multiple, closely linked beta-globin genes that differ in the timing of their expression during development. These genes have been thought to be derived from a single ancestral gene, by duplication events that occurred after the separation of the mammals and birds. We report the isolation and characterization of an atypical beta-like globin gene (omega-globin) in marsupials that appears to be more closely related to avian beta-globin genes than to other mammalian beta-globin genes, including those previously identified in marsupials. Phylogenetic analyses indicate that omega-globin evolved from an ancient gene duplication event that occurred before the divergence of mammals and birds. Furthermore, we show that omega-globin is unlinked to the previously characterized beta-globin gene cluster of marsupials, making this the first report of an orphaned beta-like globin gene expressed in a vertebrate.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cloning, Molecular Evolution, Molecular Gene Duplication Globins/chemistry,genetics Humans Mammals/classification,genetics Marsupialia/classification,genetics Molecular Sequence Data Phylogeny Polymerase Chain Reaction Sequence Alignment
Chemicals
Globins
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Wheeler D
Laboratory of Molecular Evolution, Department of Molecular Biosciences, Adelaide University, South Australia 5005, Australia.
Hope R
Cooper S B
Dolman G
Webb G C
Bottema C D
Gooley A A
Goodman M
Holland R A
References (19)
19 references, click to expand
  1. Breathing through skin in a newborn mammal.
    Nature. 1999 Feb 25;397(6721):660 PMID: 10067890
  2. Growing up with dinosaurs: molecular dates and the mammalian radiation.
    Trends Ecol Evol. 1999 Mar;14(3):113-118 PMID: 10322512
  3. Evolution and molecular characterization of a beta-globin gene from the Australian Echidna Tachyglossus aculeatus (Monotremata).
    Mol Phylogenet Evol. 1999 Jul;12(2):205-14 PMID: 10381323
  4. Gene evolution and the haemoglobins.
    Nature. 1961 Mar 4;189:704-8 PMID: 13717731
  5. Transcription of the hypersensitive site HS2 enhancer in erythroid cells.
    Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11219-23 PMID: 1454801
  6. Human hemoglobin switching.
    Science. 1991 Apr 19;252(5004):383 PMID: 2017679
  7. Gene mapping in marsupials: detection of an ancient autosomal gene cluster.
    Genomics. 1991 Apr;9(4):581-6 PMID: 2037289
  8. The genes for interleukins 3 and 5 map to the same locus on mouse chromosome 11.
    Cytogenet Cell Genet. 1989;50(2-3):107-10 PMID: 2789124
  9. Genetic applications of an inverse polymerase chain reaction.
    Genetics. 1988 Nov;120(3):621-3 PMID: 2852134
  10. CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP.
    Evolution. 1985 Jul;39(4):783-791 PMID: 28561359
  11. Evolutionary and developmental aspects of two hemoglobin beta-chain genes (epsilon M and beta M) of opossum.
    Proc Natl Acad Sci U S A. 1988 Jun;85(11):3893-7 PMID: 3375246
  12. Dating of the human-ape splitting by a molecular clock of mitochondrial DNA.
    J Mol Evol. 1985;22(2):160-74 PMID: 3934395
  13. Evolution and expression of a beta-like globin gene of the Australian marsupial Sminthopsis crassicaudata.
    Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11777-81 PMID: 8265626
  14. Blood O2 transport and Hb types in the embryonic Tammar Wallaby (Marsupialia, Macropus eugenii).
    Respir Physiol. 1993 Jan;91(1):99-109 PMID: 8441874
  15. Structural basis for the root effect in haemoglobin.
    Nat Struct Biol. 1996 Mar;3(3):275-83 PMID: 8605630
  16. A molecular and evolutionary study of the beta-globin gene family of the Australian marsupial Sminthopsis crassicaudata.
    Mol Biol Evol. 1996 Sep;13(7):1012-22 PMID: 8752008
  17. Characterization of the embryonic globin chains of the marsupial Tammar wallaby, Macropus eugenii.
    Eur J Biochem. 1997 Sep 15;248(3):864-71 PMID: 9342240
  18. Hemoglobins from bacteria to man: evolution of different patterns of gene expression.
    J Exp Biol. 1998 Apr;201(Pt 8):1099-117 PMID: 9510523
  19. Embryonic globins of the marsupial the Tammar Wallaby (Macropus eugenii): bird like and mammal like.
    Clin Exp Pharmacol Physiol. 1998 Sep;25(9):740-4 PMID: 9750967
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.98.3.1101
Published
2001-01-30
Pages
1101-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC14715
Subset
IM
Databases
GENBANK
AY014769, AY014770, AY014771, AY014772, AY014773, AY014774, AY014775
Corrections
CommentIn
PMID: 11171947
External Links
PubMed source DOI: 10.1073/pnas.98.3.1101 PMC Full Text View journal details
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