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PMID: 11133360 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Random genetic drift determines the level of mutant mtDNA in human primary oocytes.

American journal of human genetics ·Vol. 68 ·No. 2 ·2001-02-00 ·Pages 533-6

Brown DT, Samuels DC, Michael EM, Turnbull DM, Chinnery PF

Abstract

We measured the proportion of mutant mtDNA (mutation load) in 82 primary oocytes from a woman who harbored the A3243G mtDNA mutation. The frequency distribution of mutation load indicates that random drift is the principal mechanism that determines the level of mutant mtDNA within individual oocytes.

MeSH Terms
DNA, Mitochondrial/genetics Family Health Female Gene Frequency Humans Male Molecular Sequence Data Oocytes/metabolism Pedigree Point Mutation/genetics
Chemicals
DNA, Mitochondrial
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Brown D T
Department of Neurology, The University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, United Kingdom.
Samuels D C
Michael E M
Turnbull D M
Chinnery P F
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
DOI
10.1086/318190
Published
2001-02-00
Epub
2000-00-29
Pages
533-6
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1235288
Subset
IM
Databases
OMIM
540000
External Links
PubMed source DOI: 10.1086/318190 PMC Full Text View journal details
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