Abstract
Saccharomyces cerevisiae mutants that fail to complete meiotic recombination are blocked by the RAD17/RAD24/MEC1 checkpoint signaling pathway in pachytene when early sporulation genes are expressed. Middle genes are not activated in checkpoint-arrested cells because the Ndt80 transcription factor is inhibited. We find that the pachytene checkpoint requires Sum1, a transcriptional repressor that recognizes a subset of Ndt80-binding sites. Mutants lacking Sum1 or Rad17 partially bypass the block to the nuclear divisions but do not form spores, while mutants lacking both Sum1 and Rad17 completely bypass the block and form morphologically normal spores. The level of Sum1 protein decreases as middle genes are expressed, and this decrease is blocked in checkpoint-arrested cells. These data suggest that Sum1 levels are regulated by the checkpoint and that progression of the meiotic divisions and spore differentiation can be differentially controlled by competition of the Sum1 repressor and Ndt80 activator for occupancy at key middle promoters.
MeSH Terms
Blotting, Northern
Cell Cycle Proteins/metabolism
Cell Nucleus/metabolism
DNA-Binding Proteins
Fungal Proteins/metabolism
Histone Deacetylases
Intracellular Signaling Peptides and Proteins
Meiosis
Microscopy, Fluorescence
Microscopy, Phase-Contrast
Models, Biological
Mutation
Nuclear Proteins/metabolism
Promoter Regions, Genetic
Protein Serine-Threonine Kinases
Recombination, Genetic
Repressor Proteins
Saccharomyces cerevisiae/genetics,physiology
Saccharomyces cerevisiae Proteins
Sirtuin 2
Sirtuins
Spores, Fungal/physiology,ultrastructure
Time Factors
Transcription Factors
Transcription, Genetic
Chemicals
Cell Cycle Proteins
DNA-Binding Proteins
Fungal Proteins
Intracellular Signaling Peptides and Proteins
NDT80 protein, S cerevisiae
Nuclear Proteins
RAD17 protein, S cerevisiae
RAD24 protein, S cerevisiae
Repressor Proteins
SUM1 protein, S cerevisiae
Saccharomyces cerevisiae Proteins
Transcription Factors
MEC1 protein, S cerevisiae
Protein Serine-Threonine Kinases
HST1 protein, S cerevisiae
Sirtuin 2
Sirtuins
Histone Deacetylases
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Lindgren A
Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Bungard D
Pierce M
Xie J
Vershon A
Winter E
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