Resistance of tumor cells to chemo- and radiotherapy modulated by the three-dimensional architecture of solid tumors and spheroids.

Antineoplastic Agents/pharmacology Benzimidazoles/metabolism Cell Communication Cell Separation/instrumentation,methods Cell Size Chromatin/metabolism DNA, Neoplasm/metabolism Drug Resistance, Neoplasm Etoposide/pharmacology Flow Cytometry/instrumentation,methods Fluorescent Dyes/metabolism Gene Expression Regulation, Neoplastic Neoplasms/drug therapy,pathology,radiotherapy Spheroids, Cellular/cytology,drug effects,radiation effects Tumor Cells, Cultured

Antineoplastic Agents Benzimidazoles Chromatin DNA, Neoplasm Fluorescent Dyes Etoposide bisbenzimide ethoxide trihydrochloride