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PMID: 11070096 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effects of environmental enrichment on gene expression in the brain.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 97 ·No. 23 ·2000-11-07 ·Pages 12880-4

Rampon C, Jiang CH, Dong H, Tang YP, Lockhart DJ, Schultz PG, Tsien JZ, Hu Y

Abstract

An enriched environment is known to promote structural changes in the brain and to enhance learning and memory performance in rodents [Hebb, D. O. (1947) Am. Psychol. 2, 306-307]. To better understand the molecular mechanisms underlying these experience-dependent cognitive changes, we have used high-density oligonucleotide microarrays to analyze gene expression in the brain. Expression of a large number of genes changes in response to enrichment training, many of which can be linked to neuronal structure, synaptic plasticity, and transmission. A number of these genes may play important roles in modulating learning and memory capacity.

MeSH Terms
Animals Brain/metabolism,physiology Cognition/physiology Gene Expression Gene Expression Profiling Mice Mice, Inbred C57BL Mice, Inbred CBA Time Factors
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Rampon C
Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121; and the Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Jiang C H
Dong H
Tang Y P
Lockhart D J
Schultz P G
Tsien J Z
Hu Y
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.97.23.12880
Published
2000-11-07
Pages
12880-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC18858
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.97.23.12880 PMC Full Text View journal details
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