Dendritic cells: new roles for Cdc42 and Rac in antigen uptake?

Current biology : CB ·Vol. 10 ·No. 20 ·2000-10-19 ·Pages R739-41

Nobes C, Marsh M

Abstract

In dendritic cells, macropinocytosis is downregulated during maturation and antigen presentation. New studies indicate a key role for Rho-family GTPases in this regulation, but what these proteins are actually doing remains a mystery.

MeSH Terms

Animals Antigens/metabolism Dendritic Cells/cytology,physiology Humans Macrophages/physiology Pinocytosis cdc42 GTP-Binding Protein/metabolism rac GTP-Binding Proteins/metabolism

Chemicals

Antigens cdc42 GTP-Binding Protein rac GTP-Binding Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Nobes C

MRC Laboratory for Molecular Cell Biology, University College London, UK. c.nobes@ucl.ac.uk

Marsh M

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(00)00736-3

c.nobes@ucl.ac.uk

Published

2000-10-19

Pages

R739-41

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(00)00736-3 View journal details

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Dendritic cells: new roles for Cdc42 and Rac in antigen uptake?

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