Structure of yeast phenylalanine transfer RNA at 2.5 A resolution.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 11 ·1975-11-00 ·Pages 4414-8

Ladner JE, Jack A, Robertus JD, Brown RS, Rhodes D, Clark BF, Klug A

Abstract

The x-ray analysis of the monoclinic form of yeast tRNAPhe has been taken to a resolution of 2.5 A by the method of isomorphous replacement. The model proposed at 3 A has been confirmed and extended to reveal additional features of the tertiary structure and of the stereochemistry. An extensive hydrogen bonding network is described involving specific interactions between bases and the ribose-phosphate backbone. The structure of a G-U base pair has been solved.

MeSH Terms

Base Sequence Hydrogen Bonding Models, Structural Nucleic Acid Conformation Phenylalanine RNA, Transfer Saccharomyces cerevisiae X-Ray Diffraction

Chemicals

Phenylalanine RNA, Transfer

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Ladner J E

Jack A

Robertus J D

Brown R S

Rhodes D

Clark B F

Klug A

References (15)

15 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.72.11.4414

Published

1975-11-00

Pages

4414-8

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC388732

Subset

External Links

PubMed source DOI: 10.1073/pnas.72.11.4414 PMC Full Text View journal details

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Structure of yeast phenylalanine transfer RNA at 2.5 A resolution.

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