Abeta-generating enzymes: recent advances in beta- and gamma-secretase research.

Alzheimer Disease/enzymology,genetics,metabolism Amyloid Precursor Protein Secretases Amyloid beta-Peptides/biosynthesis Animals Aspartic Acid Endopeptidases/genetics,metabolism Endopeptidases/metabolism Humans Macromolecular Substances Membrane Glycoproteins/genetics,metabolism Membrane Proteins/metabolism Mice Presenilin-1 Presenilin-2 Protein Processing, Post-Translational Receptors, Notch Signal Transduction

Amyloid beta-Peptides Macromolecular Substances Membrane Glycoproteins Membrane Proteins PSEN1 protein, human PSEN2 protein, human Presenilin-1 Presenilin-2 Receptors, Notch nicastrin protein Amyloid Precursor Protein Secretases Endopeptidases Aspartic Acid Endopeptidases BACE2 protein, human BACE1 protein, human Bace1 protein, mouse