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PMID: 11050406 Published · ppublish English Journal Article Review

Gene silencing: two faces of SIR2.

Current biology : CB ·Vol. 10 ·No. 19 ·2000-10-05 ·Pages R708-11

Gottschling DE

Abstract

There are still many mysteries surrounding how silenced regions of the eukaryotic genome are created and maintained. But recent discoveries about the most evolutionarily conserved silencing protein, Sir2p, have provided new mechanistic insights into these processes.

MeSH Terms
Gene Silencing Histone Deacetylases/genetics,metabolism NAD/metabolism Silent Information Regulator Proteins, Saccharomyces cerevisiae Sirtuin 2 Sirtuins Trans-Activators/genetics,metabolism
Chemicals
Silent Information Regulator Proteins, Saccharomyces cerevisiae Trans-Activators NAD SIR2 protein, S cerevisiae Sirtuin 2 Sirtuins Histone Deacetylases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Gottschling D E
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. Dgottsch@fhcrc.org
Article Info
Journal
Current biology : CB
Abbr.
Curr Biol
ISSN
0960-9822
DOI
10.1016/s0960-9822(00)00714-4
Email
dgottsch@fhcrc.org
Published
2000-10-05
Pages
R708-11
Language
English
Region
England
NLM ID
9107782
Subset
IM
External Links
PubMed source DOI: 10.1016/s0960-9822(00)00714-4 View journal details
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