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Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations.
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Separation of sublethal and lethal effects of polymorphonuclear leukocytes on Escherichia coli.
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Effect of lipopolysaccharide (LPS) chain length on interactions of bactericidal/permeability-increasing protein and its bioactive 23-kilodalton NH2-terminal fragment with isolated LPS and intact Proteus mirabilis and Escherichia coli.
Infect Immun. 1994 Jan;62(1):259-65
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Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation.
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Individual and synergistic effects of rabbit granulocyte proteins on Escherichia coli.
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Relative concentrations of endotoxin-binding proteins in body fluids during infection.
Lancet. 1994 Aug 13;344(8920):429-31
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Bactericidal/permeability-increasing protein protects vascular endothelial cells from lipopolysaccharide-induced activation and injury.
Infect Immun. 1994 Sep;62(9):3930-6
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The respiratory burst oxidase.
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J Infect Dis. 1995 Jan;171(1):153-60
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Integration of antimicrobial host defenses: role of the bactericidal/permeability-increasing protein.
Trends Microbiol. 1994 Sep;2(9):324-8
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Extracellular accumulation of potently microbicidal bactericidal/permeability-increasing protein and p15s in an evolving sterile rabbit peritoneal inflammatory exudate.
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Inhibition of endotoxin-induced activation of the coagulation and fibrinolytic pathways using a recombinant endotoxin-binding protein (rBPI23).
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Inhibition of endotoxin-induced cytokine release and neutrophil activation in humans by use of recombinant bactericidal/permeability-increasing protein.
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Activity of lipopolysaccharide-binding protein-bactericidal/permeability-increasing protein fusion peptide in an experimental model of Pseudomonas sepsis.
Antimicrob Agents Chemother. 1995 Dec;39(12):2813-5
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Recombinant endotoxin-binding protein (rBPI23) attenuates endotoxin-induced circulatory changes in humans.
J Inflamm. 1995;45(3):193-206
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Inflammatory bowel disease is associated with increased mucosal levels of bactericidal/permeability-increasing protein.
Gastroenterology. 1996 Mar;110(3):733-9
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Antibiotic proteins of polymorphonuclear leukocytes.
Eur J Haematol. 1996 May;56(5):263-77
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Autoantibodies against bactericidal/permeability-increasing protein in patients with cystic fibrosis.
QJM. 1996 Apr;89(4):259-65
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Plasma bactericidal/permeability-increasing protein concentrations in critically ill children with the sepsis syndrome.
Pediatr Infect Dis J. 1995 Dec;14(12):1087-91
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Synergistic effect of a recombinant N-terminal fragment of bactericidal/permeability-increasing protein and cefamandole in treatment of rabbit gram-negative sepsis.
Antimicrob Agents Chemother. 1996 Jan;40(1):65-9
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Expression and characterization of cysteine-modified variants of an amino-terminal fragment of bactericidal/permeability-increasing protein.
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Bacterial infection induces nitric oxide synthase in human neutrophils.
J Clin Invest. 1997 Jan 1;99(1):110-6
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Antibacterial peptides and the outer membranes of gram-negative bacilli.
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Peptide antibiotics.
Lancet. 1997 Feb 8;349(9049):418-22
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Antimicrobial peptides of leukocytes.
Curr Opin Hematol. 1997 Jan;4(1):53-8
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Antineutrophil cytoplasm autoantibodies against bactericidal/permeability-increasing protein in inflammatory bowel disease.
Gut. 1997 Jan;40(1):105-9
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Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution.
Science. 1997 Jun 20;276(5320):1861-4
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Lipopolysaccharide (LPS)-binding proteins BPI and LBP form different types of complexes with LPS.
J Biol Chem. 1997 Jul 25;272(30):18682-5
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Mechanisms of action of bactericidal/permeability-increasing protein BPI on reconstituted outer membranes of gram-negative bacteria.
Biochemistry. 1997 Aug 19;36(33):10311-9
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Bactericidal/permeability-increasing protein ameliorates hypercoagulability after hemorrhagic shock.
Thromb Res. 1997 Aug 1;87(3):323-9
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The genetic basis of microbial resistance to antimicrobial peptides.
Methods Mol Biol. 1997;78:205-15
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An opsonic function of the neutrophil bactericidal/permeability-increasing protein depends on both its N- and C-terminal domains.
Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10973-8
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Preliminary evaluation of recombinant amino-terminal fragment of human bactericidal/permeability-increasing protein in children with severe meningococcal sepsis.
Lancet. 1997 Nov 15;350(9089):1439-43
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Role of the bactericidal/permeability-increasing protein in host defence.
Curr Opin Immunol. 1998 Feb;10(1):45-9
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PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance.
Mol Microbiol. 1998 Mar;27(6):1171-82
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The bactericidal/permeability-increasing protein (BPI) is present in specific granules of human eosinophils.
Blood. 1998 Jun 15;91(12):4770-5
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The molecular basis of chronic granulomatous disease.
Springer Semin Immunopathol. 1998;19(4):417-34
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Endotoxin interactions with lipopolysaccharide-responsive cells.
Clin Infect Dis. 1999 Mar;28(3):476-81
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Recombinant bactericidal/permeability-increasing protein (rBPI21) in combination with sulfadiazine is active against Toxoplasma gondii.
Antimicrob Agents Chemother. 1999 Apr;43(4):758-62
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Bactericidal/permeability-increasing protein (rBPI21) in patients with hemorrhage due to trauma: results of a multicenter phase II clinical trial. rBPI21 Acute Hemorrhagic Trauma Study Group.
J Trauma. 1999 Apr;46(4):667-76; discussion 676-7
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Phylogenetic perspectives in innate immunity.
Science. 1999 May 21;284(5418):1313-8
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Peptide antibiotics.
Antimicrob Agents Chemother. 1999 Jun;43(6):1317-23
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Antibiotic peptides from higher eukaryotes: biology and applications.
Mol Med Today. 1999 Jul;5(7):292-7
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Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock.
J Infect Dis. 1999 Nov;180(5):1584-9
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Phagocytin: a bactericidal substance from polymorphonuclear leucocytes.
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Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein.
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Cutting edge: cationic antimicrobial peptides block the binding of lipopolysaccharide (LPS) to LPS binding protein.
J Immunol. 2000 Jan 15;164(2):549-53
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Enhancement of neonatal innate defense: effects of adding an N-terminal recombinant fragment of bactericidal/permeability-increasing protein on growth and tumor necrosis factor-inducing activity of gram-negative bacteria tested in neonatal cord blood ex vivo.
Infect Immun. 2000 Sep;68(9):5120-5
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LPS-binding proteins and receptors.
J Leukoc Biol. 1998 Jul;64(1):25-32
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Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung.
J Clin Invest. 1998 Sep 1;102(5):874-80
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Pharmacokinetics of a recombinant amino terminal fragment of bactericidal/permeability increasing protein (rBPI21) after liver surgery in rats and humans.
Shock. 1998 Sep;10(3):161-6; discussion 167-8
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Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes.
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