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PMID: 11032752 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells.

Biochemical and biophysical research communications ·Vol. 277 ·No. 2 ·2000-10-22 ·Pages 513-7

Li X, Wang Y, Debatin KM, Hug H

Abstract

HIPK2 has been described as a homoedomain-interacting protein kinase with a nuclear localization. Here we describe that HIPK2 can also associate with TRADD, a protein that interacts with tumor necrosis factor receptor type 1 (TNF-R1). Under the conditions where HIPK2/TRADD association was found, no direct interaction of HIPK2 with CD95, TNF-R1, FADD or caspase-8 could be detected. Therefore, HIPK2 may play a role in TNF-R1 mediated signaling.

MeSH Terms
Antibodies, Monoclonal/metabolism Blotting, Western Carrier Proteins/metabolism Caspase 8 Caspase 9 Caspases/metabolism Cell Line Cell Nucleus/metabolism DNA, Complementary/metabolism Fas Ligand Protein Humans Membrane Glycoproteins/metabolism Plasmids/metabolism Precipitin Tests Protein Binding Protein Kinases/metabolism Protein Serine-Threonine Kinases Proteins/metabolism Receptors, Tumor Necrosis Factor/metabolism Signal Transduction TNF Receptor-Associated Factor 1 Transfection fas Receptor/metabolism
Chemicals
Antibodies, Monoclonal Carrier Proteins DNA, Complementary FASLG protein, human Fas Ligand Protein Membrane Glycoproteins Proteins Receptors, Tumor Necrosis Factor TNF Receptor-Associated Factor 1 fas Receptor Protein Kinases HIPK2 protein, human Protein Serine-Threonine Kinases CASP8 protein, human CASP9 protein, human Caspase 8 Caspase 9 Caspases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Li X
Universitäts-Kinderklinik Ulm, Prittwitzstrasse 43, Ulm, D-89075, Germany.
Wang Y
Debatin K M
Hug H
Article Info
Journal
Biochemical and biophysical research communications
Abbr.
Biochem Biophys Res Commun
ISSN
0006-291X
DOI
10.1006/bbrc.2000.3700
Published
2000-10-22
Pages
513-7
Language
English
Region
United States
NLM ID
0372516
Subset
IM
External Links
PubMed source DOI: 10.1006/bbrc.2000.3700 View journal details
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