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PMID: 11017168 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers.

Nature neuroscience ·Vol. 3 ·No. 10 ·2000-10-00 ·Pages 977-8

Karst H, Karten YJ, Reichardt HM, de Kloet ER, Schütz G, Joëls M

Abstract

Glucocorticoids are secreted from the adrenal gland in very high amounts after stress. In the brain, these stress hormones potently modulate ionic currents, monoaminergic transmission, synaptic plasticity and cellular viability, most notably in the hippocampus where corticosteroid receptors are highly enriched. Here we show that at least some of these actions require DNA binding of glucocorticoid receptor (GR) homodimers.

MeSH Terms

Adrenal Cortex Hormones/agonists,metabolism,pharmacology Animals Binding Sites/drug effects,physiology Calcium Channels/drug effects,metabolism Cell Membrane/drug effects,metabolism Culture Techniques DNA/metabolism Hippocampus/cytology,drug effects,metabolism Mice Mice, Mutant Strains Mutagenesis, Site-Directed/physiology Pyramidal Cells/cytology,drug effects,metabolism Receptors, Glucocorticoid/chemistry,drug effects,genetics Serotonin/metabolism,pharmacology Stress, Physiological/pathology,physiopathology

Chemicals

Adrenal Cortex Hormones Calcium Channels Receptors, Glucocorticoid Serotonin DNA

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Karst H

Inst. Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands.

Karten Y J

Reichardt H M

de Kloet E R

Schütz G

Joëls M

Article Info

Journal

Nature neuroscience

Abbr.

Nat Neurosci

ISSN

1097-6256

DOI

10.1038/79910

Published

2000-10-00

Pages

977-8

Language

English

Region

United States

NLM ID

9809671

Subset

External Links

PubMed source DOI: 10.1038/79910 View journal details

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Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers.

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