Home LiteratureArticle Details
PMID: 1101268 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Somnolence, akinesia, and sensory activation of motivated behavior in the lateral hypothalamic syndrome.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 7 ·1975-07-00 ·Pages 2819-23

Levitt DR, Teitelbaum P

Abstract

After lateral hypothalamic damage in rats, somnolence, akinesia, and sensory neglect combine to produce complete aphagia. Only simple automatisms (such as grooming, chewing, licking) are present, but intense stimuli can activate more complex actions (walking, orientation, swimming). In the anorexic stage, tactile stimuli dominate in steering locomotion and "spontaneous" locomotion depends on activation from the empty stomach.

MeSH Terms
Animals Anorexia/physiopathology Behavior, Animal Feeding Behavior Female Hypothalamus/physiology Male Posture Rats Sleep Stereotaxic Techniques Swimming Time Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Levitt D R
Teitelbaum P
References (31)
31 references, click to expand
  1. AN IRRITATIVE HYPOTHESIS CONCERNING THE HYPOTHALAMIC REGULATION OF FOOD INTAKE.
    Psychol Rev. 1965 Mar;72:105-16 PMID: 14289581
  2. Specific loss of the hypoglycemic control of feeding in recovered lateral rats.
    Am J Physiol. 1967 Nov;213(5):1159-67 PMID: 6054862
  3. The nature of the suppression of food intake by lateral hypothalamic lesions in rats.
    J Physiol. 1963 Feb;165:227-45 PMID: 13969035
  4. The lateral hypothalamic syndrome: recovery of feeding and drinking after lateral hypothalamic lesions.
    Psychol Rev. 1962 Mar;69:74-90 PMID: 13920110
  5. Recovery from the failure to eat produced by hypothalamic lesions.
    Science. 1954 Nov 26;120(3126):894-5 PMID: 13216188
  6. Hypothalamic control of food intake in rats and cats.
    Yale J Biol Med. 1951 Nov;24(2):123-40 PMID: 14901884
  7. Striatal organization of feeding behavior in the decorticate rat.
    Exp Neurol. 1970 Oct;29(1):162-74 PMID: 5478361
  8. Eating caused by 6-hydroxydopamine-induced release of noradrenaline in the diencephalon of the rat.
    J Physiol. 1972 May;223(1):35-47 PMID: 4403002
  9. Sensorimotor syndrome produced by lesions of the amygdala and lateral hypothalamus.
    J Comp Physiol Psychol. 1973 Jan;82(1):37-47 PMID: 4567891
  10. Differentiation of two reticulo-hypothalamic systems regulating hippocampal activity.
    Electroencephalogr Clin Neurophysiol. 1972 Mar;32(3):209-26 PMID: 4110391
  11. Somnolence, recovery and hyposomnia following ventro-medial diencephalic lesions in the rat.
    Electroencephalogr Clin Neurophysiol. 1969 Jan;26(1):70-9 PMID: 4183231
  12. Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system.
    Acta Physiol Scand Suppl. 1971;367:95-122 PMID: 4332694
  13. Central trigeminal structures and the lateral hypothalamic syndrome in the rat.
    Science. 1974 Nov 15;186(4164):636-8 PMID: 4606321
  14. A comparison of the eating in response to hypothermic and glucoprivic challenges after nigral 6-hydroxydopamine and lateral hypothalamic electrolytic lesions in rats.
    Brain Res. 1973 May 30;55(1):229-33 PMID: 4514582
  15. The effects of posterior hypothalamic lesions on swimming movements in different water temperatures by the rat.
    Can J Psychol. 1974 Mar;28(1):102-13 PMID: 4464029
  16. Comparison of anodal and cathodal lesions and metal deposition in eliciting postoperative locomotion in the rat.
    Physiol Behav. 1974 Oct;13(4):539-51 PMID: 4445273
  17. Effects of posterior hypothalamic lesions on voluntary behavior and hippocampal electroencephalograms in the rat.
    J Comp Physiol Psychol. 1974 May;86(5):768-86 PMID: 4833583
  18. Further analysis of sensory inattention following lateral hypothalamic damage in rats.
    J Comp Physiol Psychol. 1974 Mar;86(3):375-95 PMID: 4856031
  19. The thalamic rat: general behavior, operant learning with rewarding hypothalamic stimulation, and effects of amphetamine.
    Physiol Behav. 1974 Mar;12(3):433-48 PMID: 4820139
  20. Development of grooming in mice with amputated forelimbs.
    Science. 1973 Feb 16;179(4074):704-5 PMID: 4685044
  21. The effect of hypovolemia on drinking in rats with lateral hypothalamic damage.
    Proc Soc Exp Biol Med. 1967 Mar;124(3):816-20 PMID: 5337124
  22. Starvation retards development of food and water regulations.
    J Comp Physiol Psychol. 1971 Aug;76(2):206-18 PMID: 5290736
  23. Exaggerated prandial drinking in the "recovered lateral" rat without saliva.
    J Comp Physiol Psychol. 1969 Mar;67(3):301-8 PMID: 5254591
  24. Stages of recovery and development of lateral hypothalamic control of food and water intake.
    Ann N Y Acad Sci. 1969 May 15;157(2):849-60 PMID: 5255642
  25. Sensory neglect produced by lateral hypothalamic damage.
    Science. 1971 Oct 29;174(4008):523-5 PMID: 5165007
  26. Hippocampal EEG and behavior: effects of variation in body temperature and relation of EEG to vibrissae movement, swimming and shivering.
    Physiol Behav. 1971 Apr;6(4):391-7 PMID: 5148749
  27. Loss of 2-deoxy-D-glucose induced eating in recovered lateral rats.
    Physiol Behav. 1971 Dec;7(6):881-4 PMID: 5134028
  28. Limbic-diencephalic mechanisms of voluntary movement.
    Psychol Rev. 1971 Mar;78(2):83-113 PMID: 5547375
  29. Relationship of body weight to the lateral hypothalamic feeding syndrome.
    J Comp Physiol Psychol. 1970 Jan;70(1):25-36 PMID: 5434826
  30. Hormonal effects on ontogeny of swimming ability in the rat: assessment of central nervous system development.
    Science. 1970 Apr 3;168(3927):147-50 PMID: 5417059
  31. LATERAL HYPOTHALAMIC APHAGIA: MOTOR FAILURE OR MOTIVATIONAL DEFICIT?
    Am J Physiol. 1965 Feb;208:334-42 PMID: 14259970
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.72.7.2819
Published
1975-07-00
Pages
2819-23
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC432863
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.72.7.2819 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2