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PMID: 11007365 Published · ppublish English Journal Article Review

Building better vaccines: how apoptotic cell death can induce inflammation and activate innate and adaptive immunity.

Current opinion in immunology ·Vol. 12 ·No. 5 ·2000-10-00 ·Pages 597-603

Restifo NP

Abstract

The immunological consequences of apoptosis have been hotly debated. Apoptosis was originally described as a set of cellular morphological changes that occur in the absence of inflammation but the term has been redefined on the basis of a set of conserved molecular events that include the activation of caspases. Though the apoptosis occurring during normal development is immunologically bland or even tolerizing, the apoptotic death after viral infection or after the ligation of Fas can trigger powerful innate and adaptive immune responses. The molecular machinery at the nexus of apoptosis and inflammation includes caspase-1 --an activator of IL-1beta and IL-18 - as well as the double-stranded-RNA-dependent protein kinase pathway and RNaseL pathway, which are key effectors of antiviral immunity. New proapoptotic vaccines induce immune responses that may be able to prevent or treat infectious disease and cancer.

MeSH Terms
Animals Apoptosis Endoribonucleases/physiology Humans Immunity Inflammation/etiology RNA, Double-Stranded/pharmacology Receptors, Tumor Necrosis Factor/physiology Vaccines/immunology eIF-2 Kinase/physiology
Chemicals
RNA, Double-Stranded Receptors, Tumor Necrosis Factor Vaccines eIF-2 Kinase Endoribonucleases 2-5A-dependent ribonuclease
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Restifo N P
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. restifo@nih.gov
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Article Info
Journal
Current opinion in immunology
Abbr.
Curr Opin Immunol
ISSN
0952-7915
DOI
10.1016/s0952-7915(00)00148-5
Email
restifo@nih.gov
Published
2000-10-00
Pages
597-603
Language
English
Region
England
NLM ID
8900118
PMCID
PMC1955758
Subset
IM
Grants
Intramural NIH HHS · Z01 BC010763-01 · United States
Intramural NIH HHS · Z99 CA999999 · United States
External Links
PubMed source DOI: 10.1016/s0952-7915(00)00148-5 PMC Full Text View journal details
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