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PMID: 11007361 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Cytokine-secreting tumor cell vaccines.

Current opinion in immunology ·Vol. 12 ·No. 5 ·2000-10-00 ·Pages 571-5

Mach N, Dranoff G

Abstract

Modification of the tumor microenvironment with gene transfer techniques stimulates two immune mechanisms that effectuate tumor destruction. One involves improved tumor-antigen presentation for the development of specific cellular and humoral immunity. The second involves compromise of the tumor vasculature by soluble factors and leukocytes.

MeSH Terms
Animals Cancer Vaccines/immunology Granulocyte-Macrophage Colony-Stimulating Factor/metabolism Humans Interleukin-12/metabolism
Chemicals
Cancer Vaccines Interleukin-12 Granulocyte-Macrophage Colony-Stimulating Factor
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mach N
Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Dranoff G
Article Info
Journal
Current opinion in immunology
Abbr.
Curr Opin Immunol
ISSN
0952-7915
DOI
10.1016/s0952-7915(00)00144-8
Published
2000-10-00
Pages
571-5
Language
English
Region
England
NLM ID
8900118
Subset
IM
Grants
NCI NIH HHS · CA74886 · United States
External Links
PubMed source DOI: 10.1016/s0952-7915(00)00144-8 View journal details
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