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PMID: 1100607 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Transfer ribonucleic acid methylase deficiency found in UGA supressor strains.

Journal of bacteriology ·Vol. 124 ·No. 1 ·1975-10-00 ·Pages 332-40

Reeves RH, Roth JR

Abstract

Extracts of recessive UGA suppressor strains, designated supK, are deficient in transfer ribonucleic acid (tRNA)-methylating activity when compared to wild-type extracts. Moreover, the tRNA from suppressor strains is methyl deficient when compared to wild-type tRNA. This deficiency is due to the lack of a single tRNA methylase activity in suppressor strains. UGA suppressor activity may be caused by the miscoding of one or more methyl-deficient tRNA's in supK strains.

MeSH Terms
Cell-Free System Genes, Recessive Genetic Code Methylation Mutation RNA, Bacterial/metabolism RNA, Transfer/metabolism S-Adenosylmethionine/metabolism Salmonella typhimurium/enzymology,metabolism Suppression, Genetic tRNA Methyltransferases/biosynthesis,metabolism
Chemicals
RNA, Bacterial S-Adenosylmethionine RNA, Transfer tRNA Methyltransferases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Reeves R H
Roth J R
References (32)
32 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.124.1.332-340.1975
Published
1975-10-00
Pages
332-40
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC235900
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.124.1.332-340.1975 PMC Full Text View journal details
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