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PMID: 11005849 Published · ppublish English Comment Journal Article

Glycosylphosphatidylinositol biosynthesis validated as a drug target for African sleeping sickness.

Ferguson MA

Abstract

暂无摘要

MeSH Terms
Animals Antiprotozoal Agents/pharmacology,therapeutic use Gene Expression Regulation/drug effects Glycosylphosphatidylinositols/biosynthesis,genetics Trypanosoma brucei gambiense Trypanosomiasis, African/drug therapy,metabolism
Chemicals
Antiprotozoal Agents Glycosylphosphatidylinositols
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ferguson M A
Division of Molecular Parasitology and Biological Chemistry, Wellcome Trust Biocentre, The University of Dundee, DD1 5EH Dundee, Scotland, United Kingdom. m.a.j.ferguson@dundee.ac.uk
References (28)
28 references, click to expand
  1. Cell-free synthesis of glycosyl-phosphatidylinositol precursors for the glycolipid membrane anchor of Trypanosoma brucei variant surface glycoproteins. Structural characterization of putative biosynthetic intermediates.
    J Biol Chem. 1990 Jun 5;265(16):9033-42 PMID: 1693147
  2. Selective inhibitors of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei.
    EMBO J. 1999 Nov 1;18(21):5922-30 PMID: 10545104
  3. Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins.
    Mol Biol Cell. 2000 Apr;11(4):1183-95 PMID: 10749923
  4. Specialized fatty acid synthesis in African trypanosomes: myristate for GPI anchors.
    Science. 2000 Apr 7;288(5463):140-3 PMID: 10753118
  5. Lipophosphoglycan is not required for infection of macrophages or mice by Leishmania mexicana.
    EMBO J. 2000 May 2;19(9):1953-62 PMID: 10790362
  6. Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins.
    Mol Biol Cell. 2000 May;11(5):1523-33 PMID: 10793132
  7. Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major.
    Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9258-63 PMID: 10908670
  8. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.
    EMBO J. 2000 Aug 15;19(16):4402-11 PMID: 10944123
  9. Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei.
    Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10336-41 PMID: 10954751
  10. The transferrin receptor of Trypanosoma brucei.
    Parasitol Int. 2000 Jan;48(3):191-8 PMID: 11227758
  11. Localization of variable antigens in the surface coat of Trypanosoma brucei using ferritin conjugated antibody.
    Nature. 1969 Dec 13;224(5224):1125-6 PMID: 5353729
  12. Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei.
    Parasitology. 1975 Dec;71(3):393-417 PMID: 645
  13. Glycosyl-phosphatidylinositol moiety that anchors Trypanosoma brucei variant surface glycoprotein to the membrane.
    Science. 1988 Feb 12;239(4841 Pt 1):753-9 PMID: 3340856
  14. A novel pathway for glycan assembly: biosynthesis of the glycosyl-phosphatidylinositol anchor of the trypanosome variant surface glycoprotein.
    Cell. 1989 Mar 10;56(5):793-800 PMID: 2924349
  15. A major surface glycoprotein of trypanosoma brucei is expressed transiently during development and can be regulated post-transcriptionally by glycerol or hypoxia.
    Genes Dev. 2000 Mar 1;14(5):615-26 PMID: 10716949
  16. A structural motif in the variant surface glycoproteins of Trypanosoma brucei.
    Nature. 1993 Apr 15;362(6421):603-9 PMID: 8464512
  17. The effects of phenylmethylsulfonyl fluoride on inositol-acylation and fatty acid remodeling in African trypanosomes.
    J Biol Chem. 1994 Jul 15;269(28):18694-701 PMID: 7518442
  18. Transferrin-binding protein complex is the receptor for transferrin uptake in Trypanosoma brucei.
    J Cell Biol. 1995 Dec;131(5):1173-82 PMID: 8522581
  19. Antigenic variation in trypanosomes: secrets surface slowly.
    Bioessays. 1996 Apr;18(4):283-91 PMID: 8967896
  20. PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor.
    EMBO J. 1996 Aug 15;15(16):4254-61 PMID: 8861954
  21. Functional rafts in cell membranes.
    Nature. 1997 Jun 5;387(6633):569-72 PMID: 9177342
  22. Survival of Trypanosoma brucei in the tsetse fly is enhanced by the expression of specific forms of procyclin.
    J Cell Biol. 1997 Jun 16;137(6):1369-79 PMID: 9182668
  23. GPI-anchor synthesis in mammalian cells: genes, their products, and a deficiency.
    J Biochem. 1997 Aug;122(2):251-7 PMID: 9378699
  24. Identification of a species-specific inhibitor of glycosylphosphatidylinositol synthesis.
    EMBO J. 1997 Nov 3;16(21):6374-83 PMID: 9351820
  25. Saccharomyces cerevisiae GPI10, the functional homologue of human PIG-B, is required for glycosylphosphatidylinositol-anchor synthesis.
    Biochem J. 1998 May 15;332 ( Pt 1):153-9 PMID: 9576863
  26. Developmental abnormalities of glycosylphosphatidylinositol-anchor-deficient embryos revealed by Cre/loxP system.
    Lab Invest. 1999 Mar;79(3):293-9 PMID: 10092065
  27. Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana.
    EMBO J. 1999 May 17;18(10):2746-55 PMID: 10329621
  28. The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research.
    J Cell Sci. 1999 Sep;112 ( Pt 17):2799-809 PMID: 10444375
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
2000-09-26
Pages
10673-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC34041
Subset
IM
Corrections
CommentOn
CommentOn
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