Nuclear transcripts of mouse heavy chain immunoglobulin genes contain only the expressed class of C-region sequences.

Science (New York, N.Y.) ·Vol. 204 ·No. 4397 ·1979-06-08 ·Pages 1087-8

Marcu KB, Schibler U, Perry RP

Abstract

In plasmacytoma cells producing IgG, IgA, or IgM immunoglobulin heavy chains, the large precursors of the heavy chain messenger RNA's contain nucleotide sequences that specify only the expressed class of constant region. This indicates that the switch from one class of heavy chain to another during B cell ontogeny does not occur by altered processing of a complex gene transcript.

MeSH Terms

Animals Base Sequence Cell Line Cell Nucleus/metabolism Immunoglobulin Constant Regions/genetics Immunoglobulin Heavy Chains/genetics Immunoglobulins/genetics Mice Myeloma Proteins/genetics Neoplasms, Experimental/immunology Nucleic Acid Precursors/genetics Plasmacytoma/immunology Poly A/metabolism RNA, Heterogeneous Nuclear/genetics Transcription, Genetic

Chemicals

Immunoglobulin Constant Regions Immunoglobulin Heavy Chains Immunoglobulins Myeloma Proteins Nucleic Acid Precursors RNA, Heterogeneous Nuclear Poly A

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Marcu K B

Schibler U

Perry R P

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.109919

Published

1979-06-08

Pages

1087-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.109919 View journal details

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Nuclear transcripts of mouse heavy chain immunoglobulin genes contain only the expressed class of C-region sequences.

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