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PMID: 10984448 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Active conservation of noncoding sequences revealed by three-way species comparisons.

Genome research ·Vol. 10 ·No. 9 ·2000-09-00 ·Pages 1304-6

Dubchak I, Brudno M, Loots GG, Pachter L, Mayor C, Rubin EM, Frazer KA

Abstract

Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human-mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.

MeSH Terms
Animals Conserved Sequence/genetics Dogs Humans Mice Molecular Sequence Data Sequence Alignment Species Specificity Untranslated Regions/genetics,isolation & purification
Chemicals
Untranslated Regions
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Dubchak I
Center for Bioinformatics and Computational Genomics, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Brudno M
Loots G G
Pachter L
Mayor C
Rubin E M
Frazer K A
References (8)
8 references, click to expand
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Article Info
Journal
Genome research
Abbr.
Genome Res
ISSN
1088-9051
DOI
10.1101/gr.142200
Published
2000-09-00
Pages
1304-6
Language
English
Region
United States
NLM ID
9518021
PMCID
PMC310906
Subset
IM
Grants
NIGMS NIH HHS · GM-5748202 · United States
Databases
GENBANK
AF276990
External Links
PubMed source DOI: 10.1101/gr.142200 PMC Full Text View journal details
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