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PMID: 10981625 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Recent advances in structure-based rational drug design.

Current opinion in structural biology ·Vol. 10 ·No. 4 ·2000-08-00 ·Pages 401-4

Gane PJ, Dean PM

Abstract

Two approaches to structure-based drug design, that is, the docking of known compounds into a target protein and molecular assembly in situ, are seen to be merging technologies. The need for structural information about drug-protein complexes is now fundamental for drug discovery.

MeSH Terms
Animals Drug Design Humans Protein Engineering Structure-Activity Relationship
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gane P J
De Novo Pharmaceuticals Ltd., Cambridge, UK. paul.gane@ddg.phar.cam.ac.uk
Dean P M
Article Info
Journal
Current opinion in structural biology
Abbr.
Curr Opin Struct Biol
ISSN
0959-440X
DOI
10.1016/s0959-440x(00)00105-6
Email
paul.gane@ddg.phar.cam.ac.uk
Published
2000-08-00
Pages
401-4
Language
English
Region
England
NLM ID
9107784
Subset
IM
External Links
PubMed source DOI: 10.1016/s0959-440x(00)00105-6 View journal details
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