Rate stimulation of deoxyribonucleic acid synthesis after inhibition.
The degree to which the rate of deoxyribonucleic acid synthesis in thy- cultures of Escherichia coli is stimulated after a period of thymine starvation is shown to be a function of the concentration of thymine present as well as of the culture doubling time. Inhibition of deoxyribonucleic acid synthesis by nalidixic acid yields comparable results. Periods of thymine starvation exceeding one doubling time appear to cause an irreversible inactivation of a fraction of the replication forks in the culture.
19 references, click to expand
-
Evidence for the bidirectional replications of the Escherichia coli chromosome.Nat New Biol. 1971 Aug 4;232(31):137-40 PMID: 4937091
-
Studies on the acid-soluble nucleotide pool in thymine-requiring mutants of Escherichia coli during thymine starvation. 3. On the regulation of the deoxyadenosine triphosphate and deoxycytidine triphosphate pools of Escherichia coli.Biochim Biophys Acta. 1966 Oct 24;129(1):104-15 PMID: 4226256
-
Origin and sequence of chromosome replication in Escherichia coli.J Mol Biol. 1972 Oct 14;70(3):549-66 PMID: 4563262
-
The chromosome of Bacillus subtilis. I. Theory of marker frequency analysis.Genetics. 1965 Oct;52(4):747-57 PMID: 4953222
-
Replication time of the chromosome in thymineless mutants of Escherichia coli.J Mol Biol. 1971 Aug 28;60(1):65-74 PMID: 4937194
-
Effect of thymine concentration on the replication velocity of DNA in a thymineless mutant of Escherichia coli.Nature. 1970 Apr 11;226(5241):126-31 PMID: 4908371
-
"Replisome"-controlled initiation of DNA replication.J Theor Biol. 1971 Jul;32(1):81-92 PMID: 4933065
-
DNA synthesis during the division cycle of rapidly growing Escherichia coli B/r.J Mol Biol. 1968 Feb 14;31(3):507-18 PMID: 4866336
-
Recovery from "thymineless death" in Escherichia coli 15T.Biochem Biophys Res Commun. 1967 Oct 26;29(2):172-7 PMID: 4864067
-
Control of DNA replication by membrane.Nature. 1968 Aug 3;219(5153):485-6 PMID: 4875778
-
Chromosome replication and cell division in Escherichia coli 15T after growth in the absence of DNA synthesis.Nature. 1968 Sep 7;219(5158):1079-80 PMID: 4876942
-
Relationship between cell size and time of initiation of DNA replication.Nature. 1968 Sep 7;219(5158):1077-9 PMID: 4876941
-
STUDIES ON UNBALANCED GROWTH IN ESCHERICHIA COLI.Proc Natl Acad Sci U S A. 1954 Oct;40(10):885-93 PMID: 16589586
-
MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.II. INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS.J Bacteriol. 1965 Apr;89:1068-74 PMID: 14276097
-
INDUCTION OF REPLICATION BY THYMINE STARVATION AT THE CHROMOSOME ORIGIN IN ESCHERICHIA COLI.J Mol Biol. 1964 Aug;9:288-307 PMID: 14202267
-
The bacterial chromosome and its manner of replication as seen by autoradiography.J Mol Biol. 1963 Mar;6:208-13 PMID: 14017761
-
Growth rate and generation time of bacteria, with special reference to continuous culture.J Gen Microbiol. 1956 Dec;15(3):492-511 PMID: 13385433
-
Synchronization of division of a thymineless mutant of Escherichia coli.J Bacteriol. 1956 Jul;72(1):115-23 PMID: 13345785
-
Induction of excessive deoxyribonucleic acid synthesis in Escherichia coli by nalidixic acid.J Bacteriol. 1967 Nov;94(5):1664-71 PMID: 4862201
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
