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题目:: Natural killer cells determine the outcome of B cell-mediated autoimmunity.
作者:: Shi(F D),Wang(H B),Li(H),Hong(S),Taniguchi(M),Link(H),Van Kaer(L),Ljunggren(H G)
状态:: 发布时间2001-03-28 , 更新时间 2008-11-21
期刊:: Nat Immunol
摘要:: Natural killer (NK) cells can affect the outcome of adaptive immune responses. NK cells, but not NK1.1+T cells, were found to participate in the development of myasthenia gravis (a T cell-dependent, B cell- and antibody-mediated autoimmune disease) in C57BL/6 mice. The requirement for NK cells was reflected by the lack of a type I helper T cell response and antibodies to the acetylcholine receptor in both NK1.1+ cell-depleted and NK cell-deficient IL-18-/- mice. These findings establish a previously unrecognized link between NK cells and autoreactive T and B cells.
语言:: eng
DOI:: 10.1038/79792

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