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题目:: Mutations of the bak gene in human gastric and colorectal cancers.
作者:: Kondo(S),Shinomura(Y),Miyazaki(Y),Kiyohara(T),Tsutsui(S),Kitamura(S),Nagasawa(Y),Nakahara(M),Kanayama(S),Matsuzawa(Y)
状态:: 发布时间2000-09-14 , 更新时间 2005-11-17
期刊:: Cancer Res
摘要:: The Bcl-2 homologue Bak is a potent inducer of apoptosis. We performed PCR-based single-strand conformational polymorphism and sequencing analysis of the entire coding region of the bak gene (exons 2-6) in 24 primary gastric cancers (6 early-stage and 18 advanced-stage cancers) and 20 primary colorectal cancers (6 early-stage and 14 advanced-stage cancers). The data herein demonstrate, for the first time, the mutation of the bak gene in gastric and colorectal cancers. Missense bak gene mutations were observed in 3 of 24 (12.5%) gastric cancers and 2 of 20 (10.0%) colorectal cancers. Sequence alterations without amino acid alteration were observed 1 of 24 (4.2%) gastric cancers and 2 of 20 (10.0%) colorectal cancers. Mutations in the bak gene were observed only in advanced-stage gastrointestinal cancers but not in early-stage cancers. Our observations suggest that mutations in this gene predispose bearers to the development of gastrointestinal malignancies in at least a subset of the cases.
语言:: eng
DOI:

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