Neurosteroid analogues. 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3alpha, 5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one.

Anesthetics/chemical synthesis,chemistry,metabolism Animals Binding, Competitive Brain/metabolism Crystallography, X-Ray Electrophysiology Homosteroids/chemical synthesis,chemistry,metabolism In Vitro Techniques Molecular Conformation Oocytes Pregnanes/chemical synthesis,chemistry,metabolism Rats Receptors, GABA-A/metabolism,physiology Structure-Activity Relationship Xenopus laevis

Anesthetics Homosteroids Pregnanes Receptors, GABA-A