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PMID: 1095490 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Factors affecting filamentation in Candida albicans: changes in respiratory activity of Candida albicans during filamentation.

Infection and immunity ·Vol. 12 ·No. 1 ·1975-07-00 ·Pages 119-27

Land GA, McDonald WC, Stjernholm RL, Friedman L

Abstract

Glucose metabolism and respiration of Candida albicans were compared under conditions which permitted either maximal filamentous or maximal yeast growth. Changes in metabolism were monitored by comparing the quantities of ethanol produced, CO2 evolved, and oxygen consumed. Filamenting cultures produced more ethanol and less CO2 than yeasts, with oxygen consumption in the former concomitantly slower than that of the latter. Studies involving cofactors and inhibitors associated with electron transport imply that a transfer of electrons away from flavoprotein is required for maintenance of yeast morphology. Conditions consistent with a buildup of reduced flavoprotein, however, favored filament formation. These changes were expressed metabolically as a shift from an aerobic to a fermentative metabolism. The results presented are consistent with hypotheses correlating filament production with changes in carbohydrate metabolism and an interruption of electron transfer within the cell.

MeSH Terms
Acridines/pharmacology Candida albicans/metabolism Carbon Dioxide/biosynthesis Carbon Radioisotopes Chloramphenicol/pharmacology Deoxyglucose/pharmacology Electron Transport Ethanol/biosynthesis Glucose/metabolism Iodoacetates/pharmacology Mitochondria/drug effects Oxygen Consumption Quinacrine/pharmacology
Chemicals
Acridines Carbon Radioisotopes Iodoacetates Carbon Dioxide Ethanol Chloramphenicol Deoxyglucose Quinacrine Glucose
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Land G A
McDonald W C
Stjernholm R L
Friedman L
References (39)
39 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.12.1.119-127.1975
Published
1975-07-00
Pages
119-27
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC415254
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.12.1.119-127.1975 PMC Full Text View journal details
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