Abstract
Induction of virus-specific T-cell responses in mucosal as well as systemic compartments of the immune system is likely to be a critical feature of an effective AIDS vaccine. We investigated whether virus-specific CD8(+) lymphocytes induced in rhesus macaques by immunization with attenuated simian immunodeficiency virus (SIV), an approach that is highly effective in eliciting protection against mucosal challenge, express the mucosa-homing receptor alpha4beta7 and traffic to the intestinal mucosa. SIV-specific CD8(+) T cells expressing alpha4beta7 were detected in peripheral blood and intestine of macaques infected with attenuated SIV. In contrast, virus-specific T cells in blood of animals immunized cutaneously by a combined DNA-modified vaccinia virus Ankara regimen did not express alpha4beta7. These results demonstrate the selective induction of SIV-specific CD8(+) T lymphocytes expressing alpha4beta7 by a vaccine approach that replicates in mucosal tissue and suggest that induction of virus-specific lymphocytes that are able to home to mucosal sites may be an important characteristic of a successful AIDS vaccine.
MeSH Terms
Animals
CD8-Positive T-Lymphocytes/immunology
Epitopes, T-Lymphocyte
Flow Cytometry
Histocompatibility Antigens Class I/immunology,pharmacology
Injections, Intravenous
Intestinal Mucosa/cytology,immunology
Macaca mulatta
Receptors, Lymphocyte Homing/immunology
SAIDS Vaccines/immunology,pharmacology
Simian Acquired Immunodeficiency Syndrome/prevention & control
T-Lymphocytes, Cytotoxic/immunology
Vaccines, Attenuated/immunology,pharmacology
Vaccines, DNA/pharmacology
Vaccinia virus/immunology
Chemicals
Epitopes, T-Lymphocyte
Histocompatibility Antigens Class I
Mamu-A 01 antigen
Receptors, Lymphocyte Homing
SAIDS Vaccines
Vaccines, Attenuated
Vaccines, DNA
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Cromwell M A
Divisions of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA.
Veazey R S
Altman J D
Mansfield K G
Glickman R
Allen T M
Watkins D I
Lackner A A
Johnson R P
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