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PMID: 10933065 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy.

Neoplasia (New York, N.Y.) ·Vol. 2 ·No. 1-2 ·2000-00-00 ·Pages 9-25

Fujimoto JG, Pitris C, Boppart SA, Brezinski ME

Abstract

Optical coherence tomography (OCT) is an emerging technology for performing high-resolution cross-sectional imaging. OCT is analogous to ultrasound imaging, except that it uses light instead of sound. OCT can provide cross-sectional images of tissue structure on the micron scale in situ and in real time. Using OCT in combination with catheters and endoscopes enables high-resolution intraluminal imaging of organ systems. OCT can function as a type of optical biopsy and is a powerful imaging technology for medical diagnostics because unlike conventional histopathology which requires removal of a tissue specimen and processing for microscopic examination, OCT can provide images of tissue in situ and in real time. OCT can be used where standard excisional biopsy is hazardous or impossible, to reduce sampling errors associated with excisional biopsy, and to guide interventional procedures. In this paper, we review OCT technology and describe its potential biomedical and clinical applications.

MeSH Terms
Animals Biopsy/methods Endoscopy/methods Female Humans Neoplasms/diagnosis,pathology Optics and Photonics Tomography/instrumentation,methods Ultrasonography/methods
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Fujimoto J G
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge 02139, USA.
Pitris C
Boppart S A
Brezinski M E
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Article Info
Journal
Neoplasia (New York, N.Y.)
Abbr.
Neoplasia
ISSN
1522-8002
DOI
10.1038/sj.neo.7900071
Published
2000-00-00
Pages
9-25
Language
English
Region
United States
NLM ID
100886622
PMCID
PMC1531864
Subset
IM
Grants
NEI NIH HHS · NIH-9-RO1-EY11289-13 · United States
NCI NIH HHS · R01 CA075289 · United States
NHLBI NIH HHS · R29 HL055686 · United States
NCI NIH HHS · NIH-9-RO1-CA75289-02 · United States
NIAMS NIH HHS · R01 AR044812 · United States
NIAMS NIH HHS · NIH-RO1-AR44812-02 · United States
NEI NIH HHS · R01 EY011289 · United States
External Links
PubMed source DOI: 10.1038/sj.neo.7900071 PMC Full Text
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