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PMID: 10933061 Published · ppublish English Journal Article

Promotion of tumor invasion by cooperation of granulocytes and macrophages activated by anti-tumor antibodies.

Neoplasia (New York, N.Y.) ·Vol. 1 ·No. 5 ·1999-11-00 ·Pages 453-60

Barbera-Guillem E, May KF, Nyhus JK, Nelson MB

Abstract

We investigated the potential role of anti-tumor antibodies and tumor antigens in the formation of immune complexes which promote matrix degradation and angiogenesis. B-cell deficient or B-cell depleted mice showed a reduction in tumor invasion and metastasis. In vitro invasion assays and in vivo models of metastasis showed that anti-sTn antibodies and sTn tumor antigens form complexes which induce granulocytes and macrophages together to mediate tumor invasion and metastasis by processes including extracellular matrix degradation and angiogenesis. These results suggest the existence of a tumor promoting role of a B-cell immune response induced by shed tumor associated antigens of solid, nonlymphoid tumors.

MeSH Terms
Animals Antibodies, Neoplasm/immunology B-Lymphocytes/immunology,metabolism Cell Line Cell Separation Collagen/metabolism Drug Combinations Female Granulocytes/immunology Humans Laminin/metabolism Liver Neoplasms, Experimental/secondary Lung Neoplasms/secondary Macrophages/immunology Mice Mice, Inbred C3H Neoplasm Invasiveness Neoplasm Transplantation Peroxidase/metabolism Proteoglycans/metabolism Receptors, Fc/metabolism Time Factors Tumor Cells, Cultured
Chemicals
Antibodies, Neoplasm Drug Combinations Laminin Proteoglycans Receptors, Fc matrigel Collagen Peroxidase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Barbera-Guillem E
BioCrystal Ltd., Westerville, OH 43082-8888, USA. ebarbera@biocrystal.com
May K F
Nyhus J K
Nelson M B
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Article Info
Journal
Neoplasia (New York, N.Y.)
Abbr.
Neoplasia
ISSN
1522-8002
DOI
10.1038/sj.neo.7900054
Email
ebarbera@biocrystal.com
Published
1999-11-00
Pages
453-60
Language
English
Region
United States
NLM ID
100886622
PMCID
PMC1508114
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.neo.7900054 PMC Full Text
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