Hyaluronan is not just a goo!

The Journal of clinical investigation ·Vol. 106 ·No. 3 ·2000-08-00 ·Pages 335-6

Toole BP

Abstract

暂无摘要

MeSH Terms

Animals Extracellular Matrix/metabolism Fetal Heart/embryology,metabolism Genes, Bacterial Glucuronosyltransferase/genetics,physiology Glycosyltransferases Hyaluronan Synthases Hyaluronic Acid/chemistry,physiology Membrane Proteins Mice Mice, Knockout Streptococcus pyogenes/enzymology,genetics,pathogenicity Transferases Virulence Xenopus Proteins

Chemicals

Membrane Proteins Xenopus Proteins Hyaluronic Acid Transferases Glycosyltransferases Glucuronosyltransferase HAS1 protein, Xenopus Hyaluronan Synthases

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Toole B P

Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.bryan.toole@tufts.edu

References (14)

14 references, click to expand

Hyaluronic acid (HA) binding to CD44 activates Rac1 and induces lamellipodia outgrowth.
J Cell Biol. 2000 Mar 20;148(6):1159-64 PMID: 10725329
Formation of hyaluronan- and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells.
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Enhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3'-kinase-dependent autocrine loop involving hyaluronic acid and CD44.
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CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration.
J Biol Chem. 2000 Jan 21;275(3):1829-38 PMID: 10636882
Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells.
J Immunol. 2000 Feb 15;164(4):2053-63 PMID: 10657658
Perturbation of hyaluronan interactions by soluble CD44 inhibits growth of murine mammary carcinoma cells in ascites.
Am J Pathol. 2000 Jun;156(6):2159-67 PMID: 10854236
Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme.
J Clin Invest. 2000 Aug;106(3):349-60 PMID: 10930438
Structural analyses on the matrical organization of glycosaminoglycans in developing endocardial cushions.
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Effects of hyaluronic acid on cardiac cushion tissue cells in collagen matrix cultures.
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Molecular cloning, identification, and sequence of the hyaluronan synthase gene from group A Streptococcus pyogenes.
J Biol Chem. 1993 Sep 15;268(26):19181-4 PMID: 8366070
Immunochemical confirmation of the primary structure of streptococcal hyaluronan synthase and synthesis of high molecular weight product by the recombinant enzyme.
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Hyaluronan synthases.
J Biol Chem. 1997 May 30;272(22):13997-4000 PMID: 9206724
Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion.
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Overproduction of hyaluronan by expression of the hyaluronan synthase Has2 enhances anchorage-independent growth and tumorigenicity.
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Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI10706

usa.bryan.toole@tufts.edu

Published

2000-08-00

Pages

335-6

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC314333

Subset

Corrections

CommentOn

PMID: 10930438

External Links

PubMed source DOI: 10.1172/JCI10706 PMC Full Text View journal details

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