Abstract
We used a multiplex nested-PCR assay for the simultaneous detection in cerebrospinal fluid (CSF) of five human herpesviruses (HVs) (cytomegalovirus [CMV], Epstein-Barr virus [EBV], varicella-zoster virus [VZV], herpes simplex virus [HSV], and human herpesvirus 6 [HHV-6]) in a clinical evaluation of human immunodeficiency virus (HIV)-infected patients with neurological disorders. This method, which has the advantages of being rapid and economical, would be of particular interest for the diagnosis of neurological syndromes caused by more than one HV. We studied 251 CSF samples from 219 patients. HV DNA was demonstrated in 93 (37%) of the CSF samples (34% of the patients). CMV was the HV most frequently detected in our patients (25%), while EBV, VZV, HSV, and HHV-6 DNAs were present in significantly fewer cases (7, 4, 3, and 1%, respectively). When results were compared with the final etiological diagnoses of the patients, the multiplex HV PCR showed high specificity for the diagnosis of CMV and VZV neurological diseases and for cerebral lymphoma (0.95, 0.97, and 0.99, respectively). The sensitivity of the assay was high for CMV disease (0.87), was low for cerebral lymphoma (0.33), and was not evaluable for VZV disease due to the small number of patients with this diagnosis. Nevertheless, detection of VZV DNA had possible diagnostic value in four of the nine cases, and EBV DNA amplification always predicted the diagnosis of cerebral lymphoma in patients with cerebral masses. Detection of HSV DNA was frequently associated with CMV amplification and fatal encephalitis. HHV-6 was not considered to have a pathogenetic role in the three cases in which it was detected. This multiplex HV PCR assay is a specific and clinically useful method for the evaluation of HIV-infected patients with neurological disorders related to HV.
MeSH Terms
AIDS-Related Opportunistic Infections/diagnosis,virology
Adult
Central Nervous System Viral Diseases/diagnosis,virology
Cerebrospinal Fluid/virology
Cytomegalovirus/genetics,isolation & purification
DNA, Viral/cerebrospinal fluid
Female
Herpesviridae/genetics,isolation & purification
Herpesviridae Infections/diagnosis,virology
Herpesvirus 3, Human/genetics,isolation & purification
Herpesvirus 4, Human/genetics,isolation & purification
Herpesvirus 6, Human/genetics,isolation & purification
Humans
Male
Middle Aged
Polymerase Chain Reaction/methods
Reproducibility of Results
Simplexvirus/genetics,isolation & purification
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Quereda C
Unidad de Enfermedades Infecciosas, Hospital Ramón y Cajal, 28034-Madrid, Spain. cqueredar@hrc.insalud.es
Corral I
Laguna F
Valencia M E
Tenorio A
Echeverria J E
Navas E
Martín-Dávila P
Moreno A
Moreno V
Gonzalez-Lahoz J M
Arribas J R
Guerrero A
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