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PMID: 10908621 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Neocortical origin and tangential migration of guidepost neurons in the lateral olfactory tract.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 20 ·No. 15 ·2000-08-01 ·Pages 5802-12

Tomioka N, Osumi N, Sato Y, Inoue T, Nakamura S, Fujisawa H, Hirata T

Abstract

The early-generated neurons designated as lot cells specifically mark the future site of the lateral olfactory tract (LOT) and guide LOT axons. We investigated the mechanism of how lot cells develop and get localized in the LOT position. Lot cells differentiated from neuroepithelial cells in all regions of the neocortex but not from those in the ganglionic eminence in culture. Cell tracing analyses demonstrated that lot cells generated from the neocortex subsequently followed a tangential migration stream ventrally toward the LOT position. Mutant mouse embryos lacking the function of transcription factor Gli3 showed disturbances of the migration stream and translocation of lot cells in the dorsal telencephalon. These results reveal a new type of neuronal migration in the telencephalon and introduce an unexpected dramatic feature of the earliest regionalization of the telencephalon.

MeSH Terms
Animals Cell Movement/physiology Cells, Cultured Cerebral Cortex/cytology,embryology DNA-Binding Proteins/genetics Epithelial Cells/cytology Female Kruppel-Like Transcription Factors Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred ICR Mice, Mutant Strains Nerve Tissue Proteins/genetics Neurons/cytology Olfactory Pathways/cytology,embryology Pregnancy Repressor Proteins Transcription Factors/genetics Xenopus Proteins Zinc Finger Protein Gli3
Chemicals
DNA-Binding Proteins GLI3 protein, Xenopus GLI3 protein, human Gli3 protein, mouse Kruppel-Like Transcription Factors Nerve Tissue Proteins Repressor Proteins Transcription Factors Xenopus Proteins Zinc Finger Protein Gli3
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Tomioka N
Division of Biological Science, Nagoya University Graduate School of Science, Japan.
Osumi N
Sato Y
Inoue T
Nakamura S
Fujisawa H
Hirata T
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
0270-6474
Published
2000-08-01
Pages
5802-12
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6772553
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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