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PMID: 1090648 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Niridazole. II. A potent long-acting suppressant of cellular hypersensitivity.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 114 ·No. 1 Pt 2 ·1975-01-00 ·Pages 279-83

Mahmoud AA, Mandel A, Warren K, Webster LT

Abstract

Niridazole, a human anthelminthic drug, is shown to be a potent long-acting suppressor of delayed hypersensitivity. Much lower doses than used in the therapy of helminth infections suppressed granuloma formation around Schistosoma mansoni eggs for periods up to 32 days and inhibited delayed footpad swelling in mice previously sensitized with eggs. Marked prolongation of skin allograft survival in mice accross the H-2 area was produced. The drug is administered orally, has been used clinically on a massive scale, and appears to be relatively free of the cytotoxic effects of most immunosuppressive agents.

MeSH Terms

Animals Benzene Edema/prevention & control Female Graft Rejection Granuloma/chemically induced,prevention & control Hindlimb/immunology Hypersensitivity, Delayed/prevention & control Intestine, Small/cytology Liver/cytology Lymph/cytology Lymph Nodes/cytology Lymphocytes/immunology Mice Mice, Inbred C57BL Niridazole/therapeutic use Schistosoma mansoni/immunology Schistosomiasis/prevention & control Skin Transplantation Spleen/cytology Thoracic Duct Transplantation, Homologous Vinyl Compounds

Chemicals

Vinyl Compounds Benzene Niridazole

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Mahmoud A A

Mandel A

Warren K

Webster L T

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1975-01-00

Pages

279-83

Language

English

Region

United States

NLM ID

2985117R

Subset

External Links

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Niridazole. II. A potent long-acting suppressant of cellular hypersensitivity.

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